Cyclodextrins as multifunctional tools for advanced biomaterials in tissue repair and regeneration

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL Bioactive Materials Pub Date : 2025-07-01 Epub Date: 2025-03-27 DOI:10.1016/j.bioactmat.2025.03.018

Yu Bin Lee , Mi-Lang Kyun , Young Ju Lee , Hye-Eun Shim , Kang Moo Huh , Sun-Woong Kang

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Abstract

Cyclodextrins (CDs), characterized by their unique cyclic oligosaccharide structure and exceptional capacity for molecular encapsulation through host-guest interactions, have garnered significant attention as versatile building blocks in advanced biomaterials. This review explores the application of CD-based biomaterials in tissue engineering and regenerative medicine, emphasizing their synthesis, physicochemical characterization, biocompatibility, and translational potential. Special emphasis is placed on the development of CD-modified hydrogels, their interaction with host-guest molecules, and their use in advanced therapeutic strategies. Additionally, we discuss various fabrication methods for CD-based biomaterials, including physical and covalent crosslinking, self-assembly, and enzymatic crosslinking, each providing unique properties suited for advanced therapeutic strategies. Safety considerations and potential regulatory challenges associated with these materials are also examined. By providing a comprehensive overview of recent advancements, this review aims to highlight the promising role of cyclodextrins as multifunctional tools in enhancing tissue repair and regeneration, paving the way for innovative therapeutic solutions in clinical settings.

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环糊精作为先进生物材料在组织修复和再生中的多功能工具

环糊精（CDs）以其独特的环寡糖结构和通过主-客体相互作用进行分子包封的特殊能力而闻名，作为先进生物材料的多功能构建模块而受到广泛关注。本文综述了基于cd的生物材料在组织工程和再生医学中的应用，重点介绍了它们的合成、理化特性、生物相容性和转化潜力。特别强调cd修饰水凝胶的发展，它们与主客体分子的相互作用，以及它们在高级治疗策略中的应用。此外，我们还讨论了基于cd的生物材料的各种制造方法，包括物理和共价交联，自组装和酶交联，每种方法都提供适合先进治疗策略的独特性能。安全方面的考虑和潜在的监管挑战与这些材料也进行了审查。通过对环糊精的最新进展进行全面的综述，本文旨在强调环糊精作为多功能工具在促进组织修复和再生方面的重要作用，为临床环境中的创新治疗方案铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.