J.C. Perrot , M. Segura , G. Flotats , C. Closa , I. Gich , C. Garcia , A. Alba , M.J. Nadal , A. Pintor , J. Terra , E. Ramirez , M. Beranuy , H. Bascuñana , V. Plaza , M.R. Güell-Rous
{"title":"Long COVID-19: Impact of a personalized rehabilitation program","authors":"J.C. Perrot , M. Segura , G. Flotats , C. Closa , I. Gich , C. Garcia , A. Alba , M.J. Nadal , A. Pintor , J. Terra , E. Ramirez , M. Beranuy , H. Bascuñana , V. Plaza , M.R. Güell-Rous","doi":"10.1016/j.rh.2025.100903","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Several guidelines have proposed specific rehabilitation programs to treat symptoms/sequelae in patients with post-acute COVID syndrome (PACS). Only a few studies show that rehabilitation reduce disability after COVID-19.</div></div><div><h3>Objective</h3><div>To describe the response to a personalized rehabilitation program in terms of exercise tolerance, muscle function, dyspnea, quality of life, and frailty state in a cohort of patients with PACS.</div></div><div><h3>Methods</h3><div>Observational prospective cohort study of community-dwelling patients. The rehabilitation program included three modalities (outpatient, home-based, and self-administered), optionally supplemented with respiratory muscle training. Study variables: 6-minute walking distance (6MWD), inspiratory muscle strength (PI<sub>max</sub>), dyspnea, muscle strength (estimated with the Medical Research Council scale and handgrip), health-related quality of life (HRQoL), and frailty estimated with the Short Physical Performance Battery (SPPB) and at 3- and 6-months following baseline.</div></div><div><h3>Results</h3><div>Of 178 patients with PACS, 101 (56.7%) were enrolled in a rehabilitation program: 41.6% home-based, 27.7% outpatient, and 24.8% self-administered. Inspiratory muscle training (IMT) was provided to 56 patients, with 50 included in the rehabilitation program and 6 (5.9%) receiving IMT alone. Significant improvements were observed at 3 months in mMRC strength (<em>p</em> <!-->=<!--> <!-->0.001), SPPB (<em>p</em> <!--><<!--> <!-->0.0001), handgrip strength (<em>p</em> <!-->=<!--> <!-->0.017), mMRC dyspnea, PI<sub>max</sub> (<em>p</em> <!--><<!--> <!-->0.0001), and 6-MWD (<em>p</em> <!-->=<!--> <!-->0.008). Improvements persisted at 6 months for mMRC strength (<em>p</em> <!-->=<!--> <!-->0.048), SPPB (<em>p</em> <!-->=<!--> <!-->0.002), PI<sub>max</sub> (<em>p</em> <!--><<!--> <!-->0.0001), and 6MWD (<em>p</em> <!-->=<!--> <!-->0.048). HRQoL mental and physical component scores improved only at 3 months.</div></div><div><h3>Conclusions</h3><div>Personalized rehabilitation for patients with PACS improved muscle parameters, dyspnoea, and exercise capacity, but not HRQoL, up to 6 months. Improvements in respiratory muscle strength were associated with reductions in dyspnoea and increased exercise capacity.</div></div>","PeriodicalId":39532,"journal":{"name":"Rehabilitacion","volume":"59 2","pages":"Article 100903"},"PeriodicalIF":0.4000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Rehabilitacion","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0048712025000234","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/28 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction
Several guidelines have proposed specific rehabilitation programs to treat symptoms/sequelae in patients with post-acute COVID syndrome (PACS). Only a few studies show that rehabilitation reduce disability after COVID-19.
Objective
To describe the response to a personalized rehabilitation program in terms of exercise tolerance, muscle function, dyspnea, quality of life, and frailty state in a cohort of patients with PACS.
Methods
Observational prospective cohort study of community-dwelling patients. The rehabilitation program included three modalities (outpatient, home-based, and self-administered), optionally supplemented with respiratory muscle training. Study variables: 6-minute walking distance (6MWD), inspiratory muscle strength (PImax), dyspnea, muscle strength (estimated with the Medical Research Council scale and handgrip), health-related quality of life (HRQoL), and frailty estimated with the Short Physical Performance Battery (SPPB) and at 3- and 6-months following baseline.
Results
Of 178 patients with PACS, 101 (56.7%) were enrolled in a rehabilitation program: 41.6% home-based, 27.7% outpatient, and 24.8% self-administered. Inspiratory muscle training (IMT) was provided to 56 patients, with 50 included in the rehabilitation program and 6 (5.9%) receiving IMT alone. Significant improvements were observed at 3 months in mMRC strength (p = 0.001), SPPB (p < 0.0001), handgrip strength (p = 0.017), mMRC dyspnea, PImax (p < 0.0001), and 6-MWD (p = 0.008). Improvements persisted at 6 months for mMRC strength (p = 0.048), SPPB (p = 0.002), PImax (p < 0.0001), and 6MWD (p = 0.048). HRQoL mental and physical component scores improved only at 3 months.
Conclusions
Personalized rehabilitation for patients with PACS improved muscle parameters, dyspnoea, and exercise capacity, but not HRQoL, up to 6 months. Improvements in respiratory muscle strength were associated with reductions in dyspnoea and increased exercise capacity.
期刊介绍：
La revista que es desde hace más de 40 años la publicación oficial de la Sociedad Española de Rehabilitación y referente de la mayoría de las Sociedades de la Especialidad de los países americanos de habla hispana. Se publican 5 números pluritemáticos al año y uno monográfico sobre un tema del mayor interés y actualidad designado por el consejo de redacción.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
