Pillararene based supramolecular nanoplatform for endoplasmic reticulum-targeting type I photodynamic and NO gas therapy

IF 7.4 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Science China Materials Pub Date : 2025-03-05 DOI:10.1007/s40843-024-3268-6

Shaoqi Xie (, ), Chang Liu (, ), Yue Cao (, ), Jiachen Xia (, ), Bing Lu (, )

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Abstract

The development of tumor-targeted multimodality therapy is an important strategy to improve the curative effects of cancer treatment. It is critical to construct such a platform that can perfectly integrate these functional entities into one. Herein, we designed a phenyl sulfonamide-modified pillararene WP5-PEG-BSA. WP5-PEG-BSA can be used to construct endoplasmic reticulum (ER)-targeting nanocarriers. Then NO donor S-nitroso-N-acetyl-D-penicillamine (SNAP) and the newly designed photosensitizer DPP-DMATPE were loaded into the nanocarriers via different paths. Under laser irradiation, DPP-DMATPE exhibited excellent type I photodynamic activity, while SNAP can release NO under the action of glutathione. The formed nanodrugs BSA-DPP/SNAP exhibited outstanding ER-targeting and high lethality towards tumor cells as well as biocompability. What’s even more worth saying is that BSA-DPP/SNAP performed well even in hypoxic tumor cells. The final experimental results in vivo again confirmed the good therapeutic effects of BSA-DPP/SNAP. As a result, a supramolecular nanoplatform that realizes highly efficient ER-targeting type I photodynamic and NO gas cancer therapy was constructed.

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基于柱芳烃的内质网靶向I型光动力和NO气体治疗超分子纳米平台

肿瘤靶向多模式治疗的发展是提高肿瘤治疗疗效的重要策略。构建这样一个能够将这些功能实体完美集成为一体的平台至关重要。在此，我们设计了一种苯基磺胺改性柱芳烃WP5-PEG-BSA。WP5-PEG-BSA可用于构建内质网靶向纳米载体。然后将NO供体s -亚硝基-n -乙酰- d -青霉胺（SNAP）和新设计的光敏剂DPP-DMATPE通过不同的途径加载到纳米载体上。在激光照射下，DPP-DMATPE表现出优异的I型光动力活性，而SNAP在谷胱甘肽的作用下可以释放NO。形成的纳米药物BSA-DPP/SNAP具有出色的er靶向性、对肿瘤细胞的高致死率和生物相容性。更值得一提的是，即使在缺氧的肿瘤细胞中，BSA-DPP/SNAP也表现良好。最终的体内实验结果再次证实了BSA-DPP/SNAP的良好治疗效果。因此，构建了一个实现高效er靶向I型光动力和NO气体肿瘤治疗的超分子纳米平台。

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来源期刊

Science China Materials Materials Science-General Materials Science

CiteScore

11.40

自引率

7.40%

发文量

949

期刊介绍： Science China Materials (SCM) is a globally peer-reviewed journal that covers all facets of materials science. It is supervised by the Chinese Academy of Sciences and co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China. The journal is jointly published monthly in both printed and electronic forms by Science China Press and Springer. The aim of SCM is to encourage communication of high-quality, innovative research results at the cutting-edge interface of materials science with chemistry, physics, biology, and engineering. It focuses on breakthroughs from around the world and aims to become a world-leading academic journal for materials science.