Aggregation-induced emission-based covalent-organic framework fluorescent probes for clinical detection of aluminum and daily prevention of Alzheimerʼs disease by naked-eye

IF 9.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Science China Chemistry Pub Date : 2024-11-07 DOI:10.1007/s11426-024-2303-x

Yun Zhao, Enpeng Xi, Ziwei Wang, Qi Ding, Kangning Liu, Jinxing Zhu, Xuhan Wu, Yiling Xie, Fuming Yang, Nan Gao, Hanjun Sun, Yajie Yang, Ye Yuan, Guangshan Zhu

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Abstract

Alzheimer’s disease (AD) is a neurodegenerative disease and a major threat to human health worldwide. The association between aluminum exposure and AD has been widely reported. Owing to the ubiquitous presence of aluminum in daily life, aluminum exposure can easily occur whenever and wherever possible. Thus, a rapid and sensitive reagent for detecting aluminum and assist in AD daily prevention for potential AD patient population is extremely needed. However, existing aluminum detection methods rely on precise instruments, which are impractical for household use. Herein, a series of aggregation-induced emission-based covalent-organic framework (AIE-COF) fluorescent probes has been designed with progressively tuned sizes and screened for aluminum detection. Among them, COF-N2 was found to have the highest response towards aluminum specifically, with a fluorescence intensity change of 19.14 times before and after chelation, which could determine the aluminum concentration by naked eye. Then, the molecular mechanism of COF-N2 fluorescence changes was explained and COF-N2 was used for both diagnose the aluminum distribution in various organs of APP/PS1 transgenic mice and quickly determine the aluminum content in daily necessities. The use of AIE-COF probes for aluminum detection provides a promising avenue for developing aluminum related AD clinical diagnosis and daily prevention tools.

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基于聚合诱导发射的共价有机框架荧光探针用于临床检测铝和日常预防阿尔茨海默病的裸眼

阿尔茨海默病（AD）是一种神经退行性疾病，是全球人类健康的主要威胁。接触铝与AD之间的关系已被广泛报道。由于铝在日常生活中无处不在，铝暴露很容易随时随地发生。因此，迫切需要一种快速灵敏的检测铝的试剂，帮助潜在的AD患者群体进行日常预防。然而，现有的铝检测方法依赖于精密的仪器，这些仪器不适合家庭使用。本文设计了一系列基于聚合诱导发射的共价有机框架（ae - cof）荧光探针，其尺寸逐渐调整，并筛选用于铝检测。其中，COF-N2对铝的特异性响应最高，螯合前后荧光强度变化为19.14倍，可通过肉眼测定铝的浓度。然后，解释COF-N2荧光变化的分子机制，利用COF-N2诊断APP/PS1转基因小鼠各器官中铝的分布，快速测定日常生活用品中铝的含量。使用ae - cof探针检测铝为开发与铝相关的阿尔茨海默病的临床诊断和日常预防工具提供了一条有前景的途径。

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来源期刊

Science China Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

14.40

自引率

7.30%

发文量

3787

审稿时长

2.2 months

期刊介绍： Science China Chemistry, co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China and published by Science China Press, publishes high-quality original research in both basic and applied chemistry. Indexed by Science Citation Index, it is a premier academic journal in the field. Categories of articles include: Highlights. Brief summaries and scholarly comments on recent research achievements in any field of chemistry. Perspectives. Concise reports on thelatest chemistry trends of interest to scientists worldwide, including discussions of research breakthroughs and interpretations of important science and funding policies. Reviews. In-depth summaries of representative results and achievements of the past 5–10 years in selected topics based on or closely related to the research expertise of the authors, providing a thorough assessment of the significance, current status, and future research directions of the field.