Acute Cervical Vagus Nerve Stimulation Modulates Gastric Slow Waves in the Distal Rat Stomach.

IF 2.9 3区医学 Q1 CLINICAL NEUROLOGY Neurogastroenterology and Motility Pub Date : 2025-07-01 Epub Date: 2025-03-27 DOI:10.1111/nmo.70030

Omkar N Athavale, Recep Avci, Alys R Clark, Leo K Cheng, Peng Du

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Abstract

Background: Gastric motility is coordinated by bioelectrical events, named slow waves, which propagate across the stomach. Gastric dysrhythmias are associated with disorders of gut-brain interaction. Electrical cervical vagus nerve stimulation (cVNS) affects gastric contractions, but associated changes in gastric slow waves have not been quantified.

Methods: Three cVNS protocols (low: 0.30 ms, 0.25 mA, 1 Hz; medium: 0.50 ms, 0.50 mA, 5 Hz; high: 1.00 ms, 1.00 mA, 10 Hz) were administered to six rats. Gastric slow waves were concurrently recorded from the serosa of the antrum and distal corpus using flexible electrode arrays. Slow wave amplitude and frequency (mean ± standard deviation) were analyzed with a mixed linear effects model.

Key results: cVNS had no effect on mean slow wave amplitude (p ≥ 0.2208). Slow wave frequency decreased during the high stimulation protocol compared to sham (3.93 ± 0.90 cpm to 3.49 ± 0.54 cpm, p = 0.0374, antrum; 3.94 ± 1.04 cpm to 3.15 ± 0.53 cpm, p < 0.0001, distal corpus) but returned to sham levels after a recovery period (p = 0.9190, antrum; p = 0.9995, distal corpus). Ectopic activation of gastric slow waves occurred during cVNS, resulting in a transient effect on gastric slow wave frequency and propagation but not amplitude.

Conclusions & inferences: Slow wave activity was modified by acute medium and high cVNS stimulation protocols with changes in propagation patterns and mean frequency. Therefore, modified slow wave activity could affect gastric motility function during acute cVNS.

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急性颈迷走神经刺激对大鼠远端胃慢波的调节作用。

背景：胃运动是由生物电事件协调的，称为慢波，它在胃中传播。胃节律紊乱与肠脑相互作用紊乱有关。颈迷走神经电刺激（cVNS）影响胃收缩，但胃慢波的相关变化尚未量化。方法：三种cVNS协议(低：0.30 ms, 0.25 mA, 1 Hz；介质：0.50 ms, 0.50 mA, 5 Hz；高：1.00 ms, 1.00 mA, 10 Hz)。使用柔性电极阵列同时记录胃窦和远端体浆膜的胃慢波。慢波振幅和频率（平均值±标准差）采用混合线性效应模型进行分析。关键结果：cVNS对平均慢波振幅无影响（p≥0.2208）。与假手术相比，高刺激方案慢波频率降低(3.93±0.90 cpm至3.49±0.54 cpm, p = 0.0374，心房；结论与推论：急性中、高cVNS刺激方案可改变慢波活动的传播模式和平均频率。因此，改良慢波活动可影响急性cVNS期间的胃运动功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurogastroenterology and Motility 医学-临床神经学

CiteScore

7.80

自引率

8.60%

发文量

178

审稿时长

3-6 weeks

期刊介绍： Neurogastroenterology & Motility (NMO) is the official Journal of the European Society of Neurogastroenterology & Motility (ESNM) and the American Neurogastroenterology and Motility Society (ANMS). It is edited by James Galligan, Albert Bredenoord, and Stephen Vanner. The editorial and peer review process is independent of the societies affiliated to the journal and publisher: Neither the ANMS, the ESNM or the Publisher have editorial decision-making power. Whenever these are relevant to the content being considered or published, the editors, journal management committee and editorial board declare their interests and affiliations.