Echocardiographic Calcium Score of Aortic Valve Correlates with Coronary Artery Calcium Score in Heterozygous Familial Hypercholesterolemia.

IF 3.4 3区生物学 Q1 BIOLOGY Life-Basel Pub Date : 2025-03-20 DOI:10.3390/life15030506

Angelo Baldassare Cefalù, Emilio Nardi, Antonina Giammanco, Carola Maria Gagliardo, Carlo Maria Barbagallo, Ludovico La Grutta, Patrizia Toia, Federica Brucato, Chiara Scrimali, Teresa Maria Grazia Fasciana, Rossella Spina, Marina Lanza, Francesco Vitale, Davide Noto, Maurizio Averna

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Abstract

Background: Patients with heterozygous familial hypercholesterolemia (HeFH) are at a high risk of atherosclerotic cardiovascular disease. The coronary artery calcification (CAC) score by the Ct-scan Agatston calcium score (ACS) > 100 classifies FH at a higher risk. The echocardiographic calcium score (ECS) evaluates aortic valve calcifications and is considered a good predictor of the atherosclerotic burden and cardiovascular outcome.

Objective: To test the ECS as a predictor of ACS > 100 in a HeFH cohort.

Methods: A coronary calcium CT scan with the calculation of ACS and an at rest-transthoracic echocardiogram with ECS evaluation were performed in 81 HeFH patients. Patients were divided into two groups according to the ACS: high-risk ACS patients (High-ACS) with Agatston value > 100 and low risk ACS patients (Low-ACS) with Agatston value ≤ 100. Patients were stratified according to ECS = 0 or ECS > 0.

Results: High-ACS patients were older than Low-ACS patients; BMI, waist circumference, and blood systolic pressure were significantly higher (p < 0.001) in High-ACS patients. The ECS predicted an ACS > 100 with sensitivity = 0.84, specificity = 0.89, accuracy = 0.86, and precision = 0.76.

Conclusions: The ECS could be a good surrogate of a coronary calcium CT scan for ACS evaluation in the specific subset of HeFH patients.

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杂合子家族性高胆固醇血症患者主动脉瓣超声心动图钙评分与冠状动脉钙评分的相关性

背景：杂合子家族性高胆固醇血症（HeFH）患者发生动脉粥样硬化性心血管疾病的风险较高。冠状动脉钙化（CAC）的ct扫描Agatston钙评分（ACS） bbbb100分类FH的高风险。超声心动图钙评分（ECS）评估主动脉瓣钙化，被认为是动脉粥样硬化负担和心血管结局的良好预测指标。目的：在HeFH队列中测试ECS作为ACS bbbb100的预测因子。方法：对81例HeFH患者行冠脉钙化CT扫描并计算ACS，静息时经胸超声心动图并评价ECS。根据ACS将患者分为两组：高危ACS患者（High-ACS）， Agatston值为bb100；低危ACS患者（low -ACS）， Agatston值≤100。根据ECS = 0或ECS >对患者进行分层。结果：高acs患者比低acs患者年龄大；高acs患者的BMI、腰围和收缩压均显著增高（p < 0.001）。ECS预测ACS bbb100的敏感性= 0.84，特异性= 0.89，准确性= 0.86，精密度= 0.76。结论：在HeFH患者的特定亚群中，ECS可以很好地替代冠状动脉钙化CT扫描来评估ACS。

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来源期刊

Life-Basel Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology

CiteScore

4.30

自引率

6.20%

发文量

1798

审稿时长

11 weeks

期刊介绍： Life (ISSN 2075-1729) is an international, peer-reviewed open access journal of scientific studies related to fundamental themes in Life Sciences, especially those concerned with the origins of life and evolution of biosystems. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers.