{"title":"Cs2CO3-Mediated Annulation of Cyclopropane-1,1-dicarbonitriles with o-Benzenediamines: Access to Substituted 2-Aminoquinoxalines","authors":"Haiwen Li, Xinyi Wan, Wenzhe Cheng, Cunde Wang","doi":"10.1021/acs.joc.4c03160","DOIUrl":null,"url":null,"abstract":"The Cs<sub>2</sub>CO<sub>3</sub>-mediated formal (4 + 2) cascade annulation strategy for the synthesis of 2-aminoquinoxalines has been developed using D–A cyclopropanes and <i>o</i>-benzenediamines as the substrates. The protocol provides an efficient method of accessing a broad range of 2-aminoquinoxaline derivatives in good to excellent yields with good functional-group tolerance.","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"18 1","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Organic Chemistry","FirstCategoryId":"1","ListUrlMain":"https://doi.org/10.1021/acs.joc.4c03160","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
The Cs2CO3-mediated formal (4 + 2) cascade annulation strategy for the synthesis of 2-aminoquinoxalines has been developed using D–A cyclopropanes and o-benzenediamines as the substrates. The protocol provides an efficient method of accessing a broad range of 2-aminoquinoxaline derivatives in good to excellent yields with good functional-group tolerance.
期刊介绍：
Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.
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