The Role of Nitric Oxide and Endothelial Hyperpolarization in Relaxation of Mesenteric Arteries of Rats with Metabolic Syndrome.

IF 0.6 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Bulletin of Experimental Biology and Medicine Pub Date : 2025-02-01 Epub Date: 2025-03-26 DOI:10.1007/s10517-025-06345-7

G I Lobov, I A Tsareva

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Abstract

Changes in the relative contribution of endothelium-produced vasodilators to the modulation of mesenteric artery reactivity were studied in Wistar rats treated with 20% fructose for 16 and 32 weeks. Rats that consumed fructose developed symptoms of metabolic syndrome. Acetylcholine-induced relaxation of phenylephrine-precontracted mesenteric arteries was reduced in rats with metabolic syndrome. The NO-mediated component of acetylcholine-induced relaxation was reduced in these rats. At the same time, arterial relaxation mediated by endothelium-dependent hyperpolarization was increased. Endothelium-independent relaxation of mesenteric arteries to sodium nitroprusside in rats with metabolic syndrome was the same as in the arteries of control rats. These results suggest that the increased contraction of mesenteric arteries caused by phenylephrine in rats with metabolic syndrome is due to decreased NO production by the endothelium. Endothelium-dependent hyperpolarization appears to partially compensates for this dysfunction.

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一氧化氮和内皮超极化在代谢综合征大鼠肠系膜动脉松弛中的作用

在给予20%果糖16周和32周的Wistar大鼠中，研究了内皮生成的血管扩张剂对肠系膜动脉反应性调节的相对贡献的变化。食用果糖的大鼠出现了代谢综合征的症状。代谢综合征大鼠乙酰胆碱诱导的苯肾上腺素预收缩肠系膜动脉松弛减少。在这些大鼠中，乙酰胆碱诱导的松弛中no介导的成分减少。同时，内皮依赖性超极化介导的动脉舒张增强。硝普钠对代谢综合征大鼠肠系膜动脉内皮非依赖性松弛作用与对照大鼠相同。这些结果提示，代谢综合征大鼠中苯肾上腺素引起的肠系膜动脉收缩增加是由于内皮细胞产生一氧化氮减少所致。内皮依赖性超极化似乎部分补偿了这种功能障碍。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.