Total Area of Interfibrillar Mitochondria in the Right Atrial Appendage Cardiomyocytes as an Index of the Functional State of the Cardiovascular System in Chronic Heart Failure.
E A Kuzheleva, A A Garganeeva, O V Tukish, K N Vitt, S L Andreev, E E Syromyatnikova, E A Vladimirova
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Abstract
The clinical significance of the total area of mitochondria index in the right atrial appendage cardiomyocytes was evaluated. The index was calculated as the ratio of the total area of interfibrillar mitochondria to the area of the interfibrillar space (SMT/SIFS). A total of 39 micrographs of cardiomyocytes from 12 patients with heart failure (left ventricular ejection fraction LV EF<50%) and with obstructive multivessel coronary artery disease were analyzed. The results of the electron microscopy study were compared with the main echocardiography parameters and the functional status of the patients. It was found that the computed SMT/SIFS index was associated with general functional status according to the 6-min walk and cardiopulmonary exercise tests.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
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