Early Detection of Local Recurrence After Rectal Cancer Resection in Asymptomatic Patients Is Essential for Survival

IF 1.9 3区医学 Q3 ONCOLOGY Journal of Surgical Oncology Pub Date : 2025-03-28 DOI:10.1002/jso.28120

Katharina Esswein, Eva Hummer, Marijana Ninkovic, Elisabeth Gasser, Veronika Kröpfl, Reinhold Kafka-Ritsch

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引用次数: 0

Abstract

Background and Objectives

Despite advancements in rectal cancer treatment, therapy of local recurrence remains a significant challenge as it has to be individualized to the extent of recurrence and prior treatment. This study aims to analyze outcomes of patients with local recurrence after resection for rectal cancer, focusing on R0-resection rates and overall survival (OS).

Methods

A retrospective cohort study included 31 patients with local recurrence after initial curative resection for rectal cancer between 2003 and 2021.

Results

Recurrence was diagnosed in 77.4% of cases during scheduled routine follow-up and 58,1% of patients reported of symptoms at the time of diagnosis. Symptomatic patients tended to be treated palliatively (66.7%, 12/18, p = 0.073). A curative treatment approach was intended in 48.4% of all patients, with 80% achieving R0-resection by surgery. The 5-year OS was significantly longer in patients achieving R0-resection (58.3% vs. 5.3%, p = 0.0) and decreased in symptomatic patients (11.1% vs. 46.2%, p = 0.025).

Conclusions

These findings emphasize the importance of early recurrence detection, optimally in a scheduled cancer follow-up.

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早期检测无症状患者直肠癌切除术后的局部复发对生存至关重要

背景和目的：尽管直肠癌治疗取得了进步，但局部复发的治疗仍然是一个重大挑战，因为它必须根据复发程度和既往治疗进行个体化治疗。本研究旨在分析直肠癌切除术后局部复发患者的预后，重点关注r0切除率和总生存期（OS）。方法：回顾性队列研究纳入了2003年至2021年间31例直肠癌初次治愈切除后局部复发的患者。结果：77.4%的患者在常规随访中诊断出复发，58.1%的患者在诊断时报告有症状。有症状的患者倾向于姑息治疗（66.7%,12/18,p = 0.073）。48.4%的患者打算采用根治性治疗方法，80%的患者通过手术实现r0切除。r0切除术患者的5年OS明显延长（58.3% vs. 5.3%, p = 0.0），有症状患者的5年OS明显缩短（11.1% vs. 46.2%, p = 0.025）。结论：这些发现强调了早期复发检测的重要性，尤其是在预定的癌症随访中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Surgical Oncology 医学-外科

CiteScore

4.70

自引率

4.00%

发文量

367

审稿时长

2 months

期刊介绍： The Journal of Surgical Oncology offers peer-reviewed, original papers in the field of surgical oncology and broadly related surgical sciences, including reports on experimental and laboratory studies. As an international journal, the editors encourage participation from leading surgeons around the world. The JSO is the representative journal for the World Federation of Surgical Oncology Societies. Publishing 16 issues in 2 volumes each year, the journal accepts Research Articles, in-depth Reviews of timely interest, Letters to the Editor, and invited Editorials. Guest Editors from the JSO Editorial Board oversee multiple special Seminars issues each year. These Seminars include multifaceted Reviews on a particular topic or current issue in surgical oncology, which are invited from experts in the field.