Relationship between blood pressure variability and vitamin B level in essential hypertension.

Abstract

The B vitamins have been observed to positively influence the prevention of hypertension, with higher intakes of vitamins B6 and B12 shown to reduce blood pressure in hypertensive patients. This study investigated the relationship between blood pressure variability (BPV) and B vitamin levels in patients with essential hypertension (EH). A total of 100 patients with EH and 100 healthy control subjects were selected. BPV indices were measured using ambulatory blood pressure monitoring, which included daytime systolic blood pressure (dSBP), daytime diastolic blood pressure (dDBP), night SBP (nSBP), night DBP (nDBP), 24-hour SBP (24hSBP), 24-hour DBP (24hDBP), 24-hour SBP standard deviation (24hSSD), 24hDBP standard deviation (24hDSD), daytime SBP standard deviation (dSSD), daytime DBP standard deviation (dDSD). Blood samples were collected to measure vitamin B6 and B12 levels. Compared to the healthy group, vitamin B6 and B12 levels in the EH group were significantly lower (P<0.05). Additionally, dSBP, dDBP, nSBP, nDBP, 24hSBP, 24hDBP, 24hSSD, 24hDSD, dSSD, dDSD, nSSD, and nDSD were significantly higher in the EH group than in the healthy group (P<0.05). BPV indices were also significantly lower in the group with higher vitamin B6 and B12 levels compared to the group with lower levels (P<0.05). Furthermore, vitamin B6 and B12 levels in the EH group were negatively correlated with BPV indices (P<0.05). To sum up BPV in patients with EH is associated with B vitamin levels, which may play a role in the progression and control of hypertension-related diseases.