Association of ABCB6 Polymorphisms and Serum Levels with Susceptibility to Antituberculosis Drug-induced Hepatotoxicity.

IF 2 Journal of gastrointestinal and liver diseases : JGLD Pub Date : 2025-03-27 DOI:10.15403/jgld-5892

Ruina Chen, Jingru Cheng, Hongqiu Pan, Lihuan Lu, Xiaomin He, Meiling Zhang, Honggang Yi, Shaowen Tang

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Abstract

Background and aims: The occurrence of anti-tuberculosis drug-induced hepatotoxicity (ATDH) deserves our attention. To explore the role of ATP-binding cassette B6 (ABCB6) polymorphisms and serum levels in the risk of antituberculosis drug-induced hepatotoxicity (ATDH).

Methods: A 1:4 matched case‒control study was conducted. Four single nucleotide polymorphisms (SNPs) and serum ABCB6 levels were analyzed, and false discovery rate (FDR) was performed to correct for multiple comparison.

Results: 224 ATDH cases and 896 controls were included. SNP rs1109867 in ABCB6 gene had a decreased risk of ATDH under dominant models (FDR corrected p-value = 0.027). Furthermore, serum ABCB6 levels at three different times in the ATDH cases were higher than those in the controls.

Conclusions: SNP rs1109867 in ABCB6 gene may contribute to the susceptibility to ATDH among patients receiving anti-TB treatment.

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ABCB6多态性和血清水平与抗结核药物肝毒性易感性的关系

背景和目的：抗结核药物诱导的肝毒性（ATDH）的发生值得我们关注。探讨ATP结合盒B6（ABCB6）多态性和血清水平在抗结核药物诱导的肝毒性（ATDH）风险中的作用：进行了一项 1:4 匹配病例对照研究。结果：共纳入 224 例 ATDH 病例和 896 例对照。在显性模型下，ABCB6 基因中的 SNP rs1109867 可降低 ATDH 的风险（经 FDR 校正的 p 值 = 0.027）。此外，ATDH病例在三个不同时期的血清ABCB6水平均高于对照组：ABCB6基因中的SNP rs1109867可能是导致接受抗结核治疗的患者易患ATDH的原因之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of gastrointestinal and liver diseases : JGLD

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