Front Cover: Instigating Visible Light Inspired DNA Impairment by ROS Harvesting Ir(III)-Cyclometallated Imidazophenanthroline Complexes Against MDA-MB-231 Cells (Eur. J. Inorg. Chem. 10/2025)

Abstract

The Front Cover demonstrates imidazophenanthroline-based iridium(III) cyclometallated complexes that are capable of generating ROS via type II and type II PDT pathways in response to light exposure; this induces DNA damage and thus, ultimately annihilates MDA-MB-231 TNBC cells. The complexes have remarkable photostability that allows them to withstand visible light. Furthermore, the complexes can oxidize NADH and GSH, which triggers oxidative stress in cancer cells. More information can be found in the Research Article by S. Ghosh and P. Paira (DOI: 10.1002/ejic.202400769).