Advancements in selective laser melting (SLM) of titanium alloy scaffolds for bone tissue engineering.

IF 8 2区 医学 Q1 ENGINEERING, BIOMEDICAL Biofabrication Pub Date : 2025-04-10 DOI:10.1088/1758-5090/adc6c0
Kelun Yan, Nor Hasrul Akhmal Ngadiman, Muhammad Zameri Mat Saman, Nur Syahirah Mustafa
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Abstract

Selective Laser Melting (SLM) has emerged as a transformative technology in bone tissue engineering, particularly for fabricating porous scaffolds from titanium alloys. These scaffolds offer a promising solution for treating critical-sized bone defects, providing mechanical support while promoting bone regeneration. A comprehensive review on recent advancements of SLM is provided by presenting a detailed analysis of cutting-edge research in the application of SLM for titanium alloy scaffold production. Key areas explored include structural designs like Triply Periodic Minimal Surfaces, material and process parameters optimization to enhance scaffold properties such as porosity, mechanical strength, and biocompatibility. Furthermore, the review emphasizes recent innovations in surface modification techniques which improve bioactivity and osseointegration to enable scaffolds to mimic the host tissues. In addition, this review provides essential insights in related to the potential of SLM to be adopted in producing personalized and high-performance medical implants. By synthesizing the latest trends and identifying key areas for future research, this paper aims to serve as a vital resource for the advancement and usage of SLM-fabricated scaffolds in clinical applications. The findings underscore the importance of continued innovation in this field, which has the potential to significantly improve patient outcomes in orthopaedics and beyond.

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钛合金骨组织工程支架的选择性激光熔化研究进展。
选择性激光熔化技术(SLM)已成为骨组织工程中的一项革命性技术,特别是用于制造钛合金多孔支架。这些支架为治疗临界尺寸的骨缺损提供了一种有希望的解决方案,在促进骨再生的同时提供机械支持。通过对SLM在钛合金支架生产中的应用的前沿研究进行详细分析,全面综述了SLM的最新进展。研究的关键领域包括结构设计,如三周期最小表面(TPMS),材料和工艺参数优化,以提高支架性能,如孔隙度、机械强度和生物相容性。此外,综述强调了最近在表面修饰技术方面的创新,这些技术可以提高生物活性和骨整合,使支架能够模拟宿主组织。此外,本综述还提供了与SLM在生产个性化和高性能医疗植入物方面的潜力相关的重要见解。通过对最新研究趋势的综合和未来研究的重点领域的确定,本文旨在为slm制备支架在临床应用中的发展和使用提供重要的资源。研究结果强调了该领域持续创新的重要性,这有可能显著改善骨科及其他领域的患者预后。
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来源期刊
Biofabrication
Biofabrication ENGINEERING, BIOMEDICAL-MATERIALS SCIENCE, BIOMATERIALS
CiteScore
17.40
自引率
3.30%
发文量
118
审稿时长
2 months
期刊介绍: Biofabrication is dedicated to advancing cutting-edge research on the utilization of cells, proteins, biological materials, and biomaterials as fundamental components for the construction of biological systems and/or therapeutic products. Additionally, it proudly serves as the official journal of the International Society for Biofabrication (ISBF).
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