Role of Lyn Immunohistochemical Staining in Progression of Colorectal Carcinoma.

Q2 Medicine Asian Pacific Journal of Cancer Prevention Pub Date : 2025-03-01 DOI:10.31557/APJCP.2025.26.3.943

Hany Y Sayed, Reda F Abdelmeguid, Dalia M Abd El-Rehim, Nisreen A A Osman, Nisreen Dm Toni

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Abstract

Objective: To investigate the immunohistochemical expression of Lyn in colorectal adenocarcinoma with its corresponding lymph node metastasis and correlation with clinicopathological characteristics.

Methods: Immunohistochemical analysis of Lyn expression was performed on 70 colorectal cancer (CRC) tissue specimens of hemicolectomy and their corresponding lymph node metastases. Clinicopathological data, including age, gender, tumor size, location, TNM stage, modified Dukes stage, tumor grade, tumor-infiltrating lymphocytes (TILs), poorly differentiated clusters (PDCs), vascular invasion, and perineural invasion (PNI), were collected and analyzed to assess correlations with Lyn expression.

Results: High Lyn expression was observed in 34.3% of CRC cases. Significant associations were found between high Lyn expression and positive nodal metastasis (p < 0.001), higher TNM stage (p = 0.003), and advanced modified Dukes stage (p = 0.001). No significant associations were found between Lyn expression and age, gender, tumor size, primary tumor location, tumor grade, TILs, PDCs, vascular invasion, or PNI (p > 0.05 for all). A significant correlation was observed between Lyn expression in primary tumors and their corresponding lymph node metastases (p = 0.033).

Conclusion: Lyn expression is significantly associated with unfavorable clinicopathological parameters, which are lymph node metastasis and advanced tumor stage, suggesting its potential role as a prognostic marker in colorectal cancer.

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Lyn免疫组织化学染色在结直肠癌进展中的作用。

目的：探讨Lyn在结直肠腺癌及其相应淋巴结转移中的免疫组织化学表达及其与临床病理特征的相关性。方法：对70例结直肠癌半结肠切除术组织标本及其相应淋巴结转移灶进行Lyn表达免疫组化分析。收集和分析临床病理资料，包括年龄、性别、肿瘤大小、位置、TNM分期、修饰Dukes分期、肿瘤分级、肿瘤浸润淋巴细胞（til）、低分化簇（PDCs）、血管浸润和神经周围浸润（PNI），以评估Lyn表达的相关性。结果：34.3%的结直肠癌患者中Lyn高表达。高Lyn表达与淋巴结阳性转移（p < 0.001）、高TNM分期（p = 0.003）和晚期改良Dukes分期（p = 0.001）有显著相关性。Lyn表达与年龄、性别、肿瘤大小、原发肿瘤位置、肿瘤分级、til、PDCs、血管侵犯或PNI之间无显著相关性（p < 0.05）。Lyn在原发肿瘤中的表达与相应的淋巴结转移有显著相关性（p = 0.033）。结论：Lyn表达与淋巴结转移和肿瘤分期等不利临床病理参数显著相关，提示其在结直肠癌预后中的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Pacific Journal of Cancer Prevention 医学-肿瘤学

CiteScore

2.80

自引率

0.00%

发文量

779

审稿时长

3 months

期刊介绍： Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation. The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally. The APJCP publishes original research results under the following categories: -Epidemiology, detection and screening. -Cellular research and bio-markers. -Identification of bio-targets and agents with novel mechanisms of action. -Optimal clinical use of existing anti-cancer agents, including combination therapies. -Radiation and surgery. -Palliative care. -Patient adherence, quality of life, satisfaction. -Health economic evaluations.