Front Cover: Total Synthesis of Antiausterity Agent Callistrilone O Reveals Promising Antitumor Activity in a Melanoma Homograft Mouse Model (ChemMedChem 7/2025)
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Abstract
Total synthesis of potent antiausterity agent callistrilone O was accomplished. The cover art illustrates that callistrilone O helped the legendary Heracles crushed a giant crab under his mighty foot to preferentially attack cancer that has adapted to nutrient deprivation, with the plant Callistemon citrinus from which it was isolated in the background. More details can be found in article 10.1002/cmdc.202400818 by Kensuke Okuda and co-workers. The cover art was designed and created by Prof. Kensuke Okuda with assistance by graphic designer Takashi Tsujino.
期刊介绍：
Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies.
ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs.
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