Cover Feature: Oxidative Coupling of Guanidines and Isocyanides Catalyzed by Nickel(II): Access to Imidazoline Derivatives with Antibacterial Activity (ChemMedChem 7/2025)

Abstract

Isis, the ancient Egyptian goddess of health and the secrets of nature, is used symbolically on the cover. Isis appears as the creator of unique imidazoles. On their head rests the crown with a nickel disk rising between the horns, symbolizing the transition metal catalysis, while the feathers are embroidered with isocyanide essential for this transition. These compounds, demonstrate potent antibacterial activity and, continuing her mission of healing, may become the key to combating the growing threat of bacterial resistance. More details can be found in article 10.1002/cmdc.202400904 by Mikhail A. Kinzhalov and co-workers.