Biocompatible silicomolybdic acid-promoted one-pot expeditious synthesis of 1,2,3-NH-triazoles†

Abstract

The present work describes a new and practical approach for the one-pot preparation of 4-aryl-NH-1,2,3-triazoles and 4-glycosyl-NH-1,2,3-triazoles from a multicomponent reaction involving aldehydes, nitroalkanes, and sodium azide in the presence of 5 mol% of silicomolybdic acid (SMA) as a versatile and biocompatible catalyst. One-pot sequential formation of C–C and C–N bonds, high reaction yield, biocompatible nature of catalyst, easy handling, and broad substrate scope of 1,2,3-triazoles are the notable advantages of the present protocol.