Catalyst and transition-metal free 1,6-conjugate addition of azobisisobutyronitrile: access to isobutyronitrile containing diarylmethanes†

IF 2.7 3区 化学 Q1 CHEMISTRY, ORGANIC Organic & Biomolecular Chemistry Pub Date : 2024-11-21 DOI:10.1039/d5ob00012b
Ajay G. Mamale , Balaji M. Ghodake , Rajesh G. Gonnade , Asish K. Bhattacharya
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Abstract

A catalyst and transition-metal free 1,6-conjugate addition of azobisisobutyronitrile to para-quinone methides for the synthesis of isobutyronitrile containing diarylmethanes has been achieved. This protocol enables the synthesis of isobutyronitrile containing diarylmethanes in good yields and with a broad substrate scope. This is the first example wherein azobisisobutyronitrile has been used as a cyanide source for 1,6-conjugate addition under catalyst and metal-free conditions.

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催化剂和无过渡金属1,6-偶氮二异丁腈的共轭加成:获得含二芳基甲烷的异丁腈。
以偶氮二异丁腈为催化剂,偶氮二异丁腈在对醌类化合物上无过渡金属1,6偶联加成,合成了含二芳基甲烷的异丁腈。该工艺可以合成含二芳基甲烷的异丁腈,产率高,底物范围广。这是在催化剂和无金属条件下将偶氮二异丁腈用作1,6-共轭加成的氰化物源的第一个例子。
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来源期刊
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry 化学-有机化学
CiteScore
5.50
自引率
9.40%
发文量
1056
审稿时长
1.3 months
期刊介绍: Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.
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