Surgical management of a giant glial hamartoma in a pediatric patient: a case report.

IF 1.2 4区 医学 Q4 CLINICAL NEUROLOGY Child's Nervous System Pub Date : 2025-03-31 DOI:10.1007/s00381-025-06792-7
Guive Sharifi, Elham Paraandavaji, Shahin Naghizadeh, Yalda Nilipour, Mohammad Ali Kazemi, Sajjad Khanbabazadeh, Farzad Taghizadeh-Hesary
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Abstract

Introduction: Glial hamartomas are benign growths of glial cells, and their management is challenging due to their rarity and variable presentation. We present a case of a giant glial hamartoma in a pediatric patient, incidentally discovered during routine imaging for a planned tonsillectomy.

Case description: A 7-year-old boy with no prior neurological symptoms was found to have a large glial hamartoma in the right frontal lobe, measuring 67 mm in height and 50 mm in transverse diameter. Imaging studies revealed a hyperdense mass with internal calcifications on CT, hypointense on T1-weighted MRI, and hyperintense on T2-weighted MRI. Histopathology confirmed the diagnosis, showing benign glial cells, Rosenthal fibers, and eosinophilic granular bodies. A multidisciplinary team decided on surgical resection due to the tumor's size. The tumor was resected without complications, and postoperative recovery was uneventful. Follow-up MRIs at 4 months and 2 years post-surgery showed no residual tumor or recurrence.

Conclusions: This case underscores the role of radiological evaluation in identifying rare asymptomatic glial hamartomas and supports surgical resection to prevent complications. Comprehensive follow-up is essential for early detection of any recurrence.

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小儿巨胶质错构瘤的手术治疗:1例报告。
神经胶质瘤是神经胶质瘤细胞的良性生长,由于其罕见和不同的表现,其治疗具有挑战性。我们提出一个病例巨大的神经胶质错构瘤在儿科患者,偶然发现在常规成像计划扁桃体切除术。病例描述:一名无神经系统症状的7岁男孩被发现在右额叶有一个大的胶质错构瘤,高67mm,横径50mm。影像学检查显示CT上有内部钙化的高密度肿块,t1加权MRI呈低信号,t2加权MRI呈高信号。组织病理学证实了诊断,显示良性胶质细胞、罗森塔尔纤维和嗜酸性颗粒体。由于肿瘤的大小,一个多学科小组决定手术切除。肿瘤切除无并发症,术后恢复顺利。术后4个月和2年随访mri未见肿瘤残留或复发。结论:本病例强调了放射学评估在识别罕见的无症状胶质错构瘤中的作用,并支持手术切除以预防并发症。全面的随访是早期发现任何复发的必要条件。
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来源期刊
Child's Nervous System
Child's Nervous System 医学-临床神经学
CiteScore
3.00
自引率
7.10%
发文量
322
审稿时长
3 months
期刊介绍: The journal has been expanded to encompass all aspects of pediatric neurosciences concerning the developmental and acquired abnormalities of the nervous system and its coverings, functional disorders, epilepsy, spasticity, basic and clinical neuro-oncology, rehabilitation and trauma. Global pediatric neurosurgery is an additional field of interest that will be considered for publication in the journal.
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