Effects of an active ankle exoskeleton on the walking biomechanics of healthy men.

IF 4.8 3区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Frontiers in Bioengineering and Biotechnology Pub Date : 2025-03-14 eCollection Date: 2025-01-01 DOI:10.3389/fbioe.2025.1533001
Sridevi Nagaraja, Jose E Rubio, Junfei Tong, Aravind Sundaramurthy, Anup Pant, Meredith K Owen, Michael A Samaan, Brian Noehren, Jaques Reifman
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Abstract

Active lower-body exoskeleton devices can decrease the energy requirement of the human body by providing mechanical assistance to lower-body muscles. However, they also alter gait kinematics and kinetics, and it is not well understood whether such alterations are detrimental or beneficial to the human body. In this pilot study, we investigated the impact of walking with an ankle exoskeleton device on the biomechanics of men while carrying a heavy load. We collected computed tomography images and motion-capture data for five young, healthy men who walked 5 km (∼60 min) with a 22.7-kg load, with and without an active ankle exoskeleton (the ExoBoot EB60). We developed personalized musculoskeletal models and calculated the joint kinematics and kinetics for each participant under each walking condition. Without the ExoBoot, at 5 km compared to 0 km, on average, the peak trunk flexion angle increased by ∼35% and the stride length increased by ∼3.5%. In contrast, with the ExoBoot, the magnitude of the corresponding increases was smaller (∼16% and ∼2%, respectively). After the 5-km walk, compared to walking without the ExoBoot, its use considerably altered hip-related biomechanical parameters, e.g., it increased hip abduction angle by ∼17%, increased hip flexion moment by ∼3.5%, and decreased hip adduction moment by ∼19%. Finally, irrespective of distance, ExoBoot use significantly increased the stance duration and peak ankle plantarflexion angle (p < 0.001). Overall, the use of the ExoBoot induced beneficial alterations in stride length and trunk-, ankle-, and hip-related parameters for men walking with load carriage. The quantitative analysis provided by this pilot study should help guide future investigations and inform the development of standards for safe and effective use of emerging exoskeleton technologies.

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活动踝关节外骨骼对健康男性行走生物力学的影响。
主动下半身外骨骼装置可以通过为下半身肌肉提供机械辅助来减少人体的能量需求。然而,它们也会改变步态的运动学和动力学,目前还不清楚这种改变对人体是有害还是有益。在这项初步研究中,我们调查了在负重时使用脚踝外骨骼装置行走对男性生物力学的影响。我们收集了5名年轻健康男性的计算机断层扫描图像和运动捕捉数据,这些男性负重22.7 kg,行走5公里(约60分钟),有或没有活动踝关节外骨骼(ExoBoot EB60)。我们开发了个性化的肌肉骨骼模型,并计算了每个参与者在每种行走条件下的关节运动学和动力学。在没有ExoBoot的情况下,与0公里相比,在5公里时,躯干峰值弯曲角平均增加了35%,步幅增加了3.5%。相比之下,使用ExoBoot,相应的增加幅度较小(分别为~ 16%和~ 2%)。步行5公里后,与不使用ExoBoot行走相比,使用ExoBoot大大改变了髋关节相关的生物力学参数,例如,它使髋关节外展角增加了~ 17%,髋屈曲力矩增加了~ 3.5%,髋关节内收力矩减少了~ 19%。最后,与距离无关,ExoBoot的使用显著增加了站立时间和踝关节跖屈峰值角度(p < 0.001)。总的来说,使用ExoBoot对负重行走的男性在步幅、躯干、脚踝和臀部相关参数方面产生了有益的改变。这项试点研究提供的定量分析将有助于指导未来的调查,并为安全有效地使用新兴外骨骼技术的标准的制定提供信息。
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来源期刊
Frontiers in Bioengineering and Biotechnology
Frontiers in Bioengineering and Biotechnology Chemical Engineering-Bioengineering
CiteScore
8.30
自引率
5.30%
发文量
2270
审稿时长
12 weeks
期刊介绍: The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs. In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.
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