Mechanism and Application Prospect of Noncoding RNA Regulating Tumor Cell Pyroptosis.

IF 1.8 3区医学 Q3 ONCOLOGY Oncology Pub Date : 2025-03-28 DOI:10.1159/000543102

Wang Wan, Qiyang Mao, Zhuohong Ye, Dan Huang, Rongjing Zhang, Kangxian Wang, XueFeng Wang, QiaYu Wu, Zhu Liang, Chunyuan Chen

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引用次数: 0

Abstract

Background: Noncoding RNAs (ncRNAs), including microRNAs, lncRNAs, and circRNAs, play essential roles in physiological and pathological processes, including cancer, where they act as drivers or suppressors. Aberrant ncRNA expression in tumors has been linked to tumor promotion or suppression, making them potential cancer biomarkers. Pyroptosis, a newly discovered form of programmed cell death, is characterized by cell swelling, membrane rupture, and inflammation, offering a novel strategy for tumor elimination.

Summary: Pyroptosis can activate anti-tumor immunity, while ncRNAs regulate pyroptosis pathways, influencing tumorigenesis through diverse mechanisms. However, the role of ncRNAs in pyroptosis, including potential initiators and their impact on tumor resistance, immunity, and cancer progression, remains unclear. The specific role of circRNAs in pyroptosis also requires further exploration.

Key messages: This article explores the role of ncRNAs in pyroptosis, with a particular focus on ncRNA-mediated mechanisms, and highlights their potential as diagnostic and prognostic markers in cancer.

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非编码RNA调控肿瘤细胞焦亡的机制研究及应用前景。

背景：非编码 RNA（ncRNA），包括 microRNA、lncRNA 和 circRNA，在包括癌症在内的生理和病理过程中发挥着至关重要的作用，它们在这些过程中起着驱动或抑制作用。ncRNA 在肿瘤中的异常表达与肿瘤的促进或抑制有关，因此是潜在的癌症生物标志物。新发现的一种程序性细胞死亡形式--热休克，以细胞肿胀、膜破裂和炎症为特征，为消除肿瘤提供了一种新策略。摘要：热休克可激活抗肿瘤免疫，而ncRNA可调控热休克通路，通过不同机制影响肿瘤发生。然而，ncRNAs在热核酸形成过程中的作用，包括潜在的启动因子及其对肿瘤抗性、免疫和癌症进展的影响仍不清楚。circRNAs 在化脓过程中的具体作用也需要进一步探索：这篇文章探讨了ncRNA在化脓过程中的作用，尤其关注了ncRNA介导的机制，并强调了它们作为癌症诊断和预后标志物的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oncology 医学-肿瘤学

CiteScore

6.00

自引率

2.90%

发文量

审稿时长

6-12 weeks

期刊介绍： Although laboratory and clinical cancer research need to be closely linked, observations at the basic level often remain removed from medical applications. This journal works to accelerate the translation of experimental results into the clinic, and back again into the laboratory for further investigation. The fundamental purpose of this effort is to advance clinically-relevant knowledge of cancer, and improve the outcome of prevention, diagnosis and treatment of malignant disease. The journal publishes significant clinical studies from cancer programs around the world, along with important translational laboratory findings, mini-reviews (invited and submitted) and in-depth discussions of evolving and controversial topics in the oncology arena. A unique feature of the journal is a new section which focuses on rapid peer-review and subsequent publication of short reports of phase 1 and phase 2 clinical cancer trials, with a goal of insuring that high-quality clinical cancer research quickly enters the public domain, regardless of the trial’s ultimate conclusions regarding efficacy or toxicity.