{"title":"Serum circulating S100A7 and S100A15 DNA copies are elevated in patients with psoriasis and atopic dermatitis","authors":"Shuji Yamamura, Tselmeg Mijiddorj Myangat, Soichiro Sawamura, Shuichi Shimada, Kayo Kashiwada-Nakamura, Ikko Kajihara, Katsunari Makino, Shinichi Masuguchi, Satoshi Fukushima","doi":"10.1111/1346-8138.17727","DOIUrl":null,"url":null,"abstract":"<p>In this study, we investigated whether circulating <i>S100A7</i> and <i>S100A15</i> DNA copies in cell-free DNA (cfDNA) are elevated in patients with psoriasis and atopic dermatitis (AD) and their levels are correlated with clinical findings. Serum cfDNA was obtained from 124 psoriasis patients and 45 AD patients. Circulating <i>S100A7</i> and <i>S100A15</i> DNA copies in psoriasis and AD patients were significantly higher than in healthy controls. Although circulating <i>S100A7</i> and <i>S100A15</i> DNA copies showed a significant positive correlation with the Psoriasis Severity and Area Index (PASI) scores in patients with severe psoriasis (PASI ≥ 10), in AD patients there was no significant correlation between their levels and disease severity. Furthermore, in psoriasis patients, circulating <i>S100A15</i> DNA copies were significantly decreased in patients after treatment compared with patients before treatment.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 6","pages":"1098-1102"},"PeriodicalIF":2.7000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Dermatology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/1346-8138.17727","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
In this study, we investigated whether circulating S100A7 and S100A15 DNA copies in cell-free DNA (cfDNA) are elevated in patients with psoriasis and atopic dermatitis (AD) and their levels are correlated with clinical findings. Serum cfDNA was obtained from 124 psoriasis patients and 45 AD patients. Circulating S100A7 and S100A15 DNA copies in psoriasis and AD patients were significantly higher than in healthy controls. Although circulating S100A7 and S100A15 DNA copies showed a significant positive correlation with the Psoriasis Severity and Area Index (PASI) scores in patients with severe psoriasis (PASI ≥ 10), in AD patients there was no significant correlation between their levels and disease severity. Furthermore, in psoriasis patients, circulating S100A15 DNA copies were significantly decreased in patients after treatment compared with patients before treatment.
期刊介绍：
The Journal of Dermatology is the official peer-reviewed publication of the Japanese Dermatological Association and the Asian Dermatological Association. The journal aims to provide a forum for the exchange of information about new and significant research in dermatology and to promote the discipline of dermatology in Japan and throughout the world. Research articles are supplemented by reviews, theoretical articles, special features, commentaries, book reviews and proceedings of workshops and conferences.
Preliminary or short reports and letters to the editor of two printed pages or less will be published as soon as possible. Papers in all fields of dermatology will be considered.
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