Gaofeng Feng, Chao Zhang, Jing-Yao He, Tao Cai, Wenzhe Xu, Jian Jin
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引用次数: 0
Abstract
A cerium ammonium nitrate (CAN)-promoted C(sp2)–N coupling reaction of secondary amides with aryl boronic acids has been realized, providing a new entry for the construction of structurally diverse tertiary aryl amides, which are widely found in various biologically active molecules. Preliminary mechanistic studies indicated that a radical pathway may be involved in the C(sp2)–N coupling process. Compared with other metal-catalyzed methods, which in some cases require well-designed catalysts, preassembled directing groups, and/or complicated operations, this methodology features a ligand- and directing group-free process, as well as ease of handling.
期刊介绍：
Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.
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