Can Bacillus paranthracis cause bacteremia in a T-ALL patient? WGS-based diagnosis.

IF 1.2 4区医学 Q4 INFECTIOUS DISEASES Journal of Infection in Developing Countries Pub Date : 2025-03-31 DOI:10.3855/jidc.20080

Serap Süzük Yıldız, Ayşegül Polat, Süleyman Yalçın, Mert Emre Ölmez, Tahir Darçın, Kerem Özdel, İpek Mumcuoğlu, Tuba Dal

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Abstract

Introduction: Most of Bacillus spp. generally avirulent species in healthy patients, but if there is a fragile in the patient, especially their immune system, Bacillus spp. can be an agent for infections.

Case report: In this case, we report that Bacillus paranthracis, diagnosed by whole genome sequencing, is responsible for bacteremia in a T-ALL patient. A 26-year-old male patient was diagnosed with T-cell acute lymphoblastic leukemia. Bacillus paranthracis was isolated from two sets of blood cultures obtained from a patient with febrile neutropenia.

Results: The bacteria was identified as Bacillus cereus group in a routine microbiology laboratory by MALDI TOF MS. Then whole genome sequencing (WGS) confirmed its name as Bacillus paranthracis. The pathogenicity of the bacterium, especially in immunocompromised patients, has also been demonstrated by WGS.

Conclusions: In a microbiology laboratory, the use of Whole Genome Sequencing (WGS) is important for diagnosing diseases, especially in immunocompromised patients. It will serve the management of these patients for infection control.

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副嗜血杆菌能引起T-ALL患者的菌血症吗？WGS-based诊断。

简介：大多数芽孢杆菌对健康患者一般是无毒的，但如果患者体内有一个脆弱的系统，尤其是他们的免疫系统，芽孢杆菌可成为感染的媒介。病例报告：在这种情况下，我们报告，由全基因组测序诊断的副芽孢杆菌，是负责T-ALL患者菌血症。一位26岁的男性患者被诊断患有t细胞急性淋巴细胞白血病。从发热性中性粒细胞减少症患者的两组血液培养物中分离出了副嗜血杆菌。结果：常规微生物实验室MALDI TOF ms鉴定该菌为蜡样芽孢杆菌群，全基因组测序（WGS）鉴定为副芽孢杆菌。WGS也证实了这种细菌的致病性，特别是在免疫功能低下的患者中。结论：在微生物实验室中，全基因组测序（WGS）对疾病诊断具有重要意义，特别是对免疫功能低下患者。它将服务于这些患者的感染控制管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Infection in Developing Countries INFECTIOUS DISEASES-

CiteScore

3.70

自引率

5.30%

发文量

239

审稿时长

4-8 weeks

期刊介绍： The Journal of Infection in Developing Countries (JIDC) is an international journal, intended for the publication of scientific articles from Developing Countries by scientists from Developing Countries. JIDC is an independent, on-line publication with an international editorial board. JIDC is open access with no cost to view or download articles and reasonable cost for publication of research artcles, making JIDC easily availiable to scientists from resource restricted regions.