Organic Molecules as a Bridge Connecting Photoelectrochemistry and Fluorescence for Dual-Signal Assay

IF 6.7 1区化学 Q1 CHEMISTRY, ANALYTICAL Analytical Chemistry Pub Date : 2025-04-03 DOI:10.1021/acs.analchem.4c06431

Jiaxing Chang, Zhinan Zhang, Chulin Qu, Qingzhi Han, Li Xu

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Abstract

We report a strategy based on pyridyl-anchored organic small-molecule fluorescent probes to develop a dual-signal sensing platform. The strategy accomplishes an intelligent integration of fluorescence analysis with photoelectrochemical (PEC) sensing, thereby enabling rapid and precise detection of hypochlorite. In this work, the natural dye chromone was selected as the fluorophore for generating fluorescent signals. Meanwhile, by using phenothiazine (PTZ) as the specific recognition group and pyridine as the anchoring moiety, we designed and synthesized a novel organic small-molecule fluorescent probe. The obtained probe was used as a photosensitive material anchored to the TiO₂ surface via N → Ti bonds, to form an FTO/TiO₂/FPTZ-1 heterostructure-based dual-signal sensing platform for the detection of hypochlorite. This sensing platform has the characteristics of high specificity, sensitivity, and ease of preparation, enabling rapid qualitative fluorescence readout and quantitative photoelectrochemical readout of hypochlorite, with a limit of detection of 0.288 μM for fluorescence and 1.37 nM for PEC.

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有机分子作为连接光电化学和荧光双信号分析的桥梁

我们报告了一种基于吡啶锚定有机小分子荧光探针开发双信号传感平台的策略。该策略实现了荧光分析与光电化学（PEC）传感的智能集成，从而实现了次氯酸盐的快速和精确检测。本研究选择天然染料色素作为荧光团产生荧光信号。同时，以吩噻嗪（PTZ）为特异识别基团，吡啶为锚定基团，设计并合成了一种新型的有机小分子荧光探针。将所得探针作为光敏材料，通过N→Ti键固定在TiO2表面，形成基于FTO/TiO2/FPTZ-1异质结构的双信号检测平台，用于次氯酸盐的检测。该传感平台具有特异度高、灵敏度高、制备方便等特点，可实现次氯酸盐的定性荧光和定量光电化学读出，荧光和光电化学的检出限分别为0.288 μM和1.37 nM。

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来源期刊

Analytical Chemistry 化学-分析化学

CiteScore

12.10

自引率

12.20%

发文量

1949

审稿时长

1.4 months

期刊介绍： Analytical Chemistry, a peer-reviewed research journal, focuses on disseminating new and original knowledge across all branches of analytical chemistry. Fundamental articles may explore general principles of chemical measurement science and need not directly address existing or potential analytical methodology. They can be entirely theoretical or report experimental results. Contributions may cover various phases of analytical operations, including sampling, bioanalysis, electrochemistry, mass spectrometry, microscale and nanoscale systems, environmental analysis, separations, spectroscopy, chemical reactions and selectivity, instrumentation, imaging, surface analysis, and data processing. Papers discussing known analytical methods should present a significant, original application of the method, a notable improvement, or results on an important analyte.