{"title":"Tonsils weigh in on flu-specific immunity","authors":"Petter Brodin","doi":"10.1016/j.stem.2025.03.007","DOIUrl":null,"url":null,"abstract":"Wagoner et al.<span><span><sup>1</sup></span></span> use human tonsil organoids to uncover key immune mechanisms driving influenza vaccine responses. They identify Th1 cell frequencies as a critical predictor of neutralizing antibody responses to inactivated vaccines, providing new insights into vaccine effectiveness and paving the way for more targeted vaccine development in the future.","PeriodicalId":9665,"journal":{"name":"Cell stem cell","volume":"58 1","pages":""},"PeriodicalIF":20.4000,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell stem cell","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.stem.2025.03.007","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL & TISSUE ENGINEERING","Score":null,"Total":0}
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Abstract
Wagoner et al.1 use human tonsil organoids to uncover key immune mechanisms driving influenza vaccine responses. They identify Th1 cell frequencies as a critical predictor of neutralizing antibody responses to inactivated vaccines, providing new insights into vaccine effectiveness and paving the way for more targeted vaccine development in the future.
期刊介绍：
Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.
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