Nissim Benvenisty, Jonathan S. Draper, Paul J. Gokhale, Lyn Healy, Zoe Hewitt, Deborah Hursh, Adam Hodgson, Tenneille E. Ludwig, Nancy Mah, Sarah E. McClelland, Milena Mennecozzi, Florian T. Merkle, Joanne C. Mountford, Martin Pera, Alessandro Prigione, Tristan A. Rodriguez, Andrea Rossi, Foad J. Rouhani, Kourosh Saeb-Parsy, Lucia Selfa Aspiroz, Ivana Barbaric
{"title":"A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy","authors":"Nissim Benvenisty, Jonathan S. Draper, Paul J. Gokhale, Lyn Healy, Zoe Hewitt, Deborah Hursh, Adam Hodgson, Tenneille E. Ludwig, Nancy Mah, Sarah E. McClelland, Milena Mennecozzi, Florian T. Merkle, Joanne C. Mountford, Martin Pera, Alessandro Prigione, Tristan A. Rodriguez, Andrea Rossi, Foad J. Rouhani, Kourosh Saeb-Parsy, Lucia Selfa Aspiroz, Ivana Barbaric","doi":"10.1016/j.stem.2025.03.003","DOIUrl":null,"url":null,"abstract":"Human pluripotent stem cell (hPSC)-based therapies offer promise but pose potential risks due to culture-acquired genetic variants, some of which have been linked with cancer. An international workshop addressed these concerns, highlighting the need for improved strategies to stratify variants and chart a path toward definitive guidelines in hPSC-based therapy.","PeriodicalId":9665,"journal":{"name":"Cell stem cell","volume":"44 1","pages":""},"PeriodicalIF":20.4000,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell stem cell","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.stem.2025.03.003","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL & TISSUE ENGINEERING","Score":null,"Total":0}
引用次数: 0
Abstract
Human pluripotent stem cell (hPSC)-based therapies offer promise but pose potential risks due to culture-acquired genetic variants, some of which have been linked with cancer. An international workshop addressed these concerns, highlighting the need for improved strategies to stratify variants and chart a path toward definitive guidelines in hPSC-based therapy.
期刊介绍：
Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.
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