Porous Sodium Carboxymethyl Starch Microspheres for Hemostasis and Skin Wound Healing.

Abstract

An effective and rapid hemostatic material with flexible properties for clinical wound dressings is still an unmet need. Herein, a porous sodium carboxymethyl starch (CMS-Na-P) hemostatic microsphere was successfully fabricated through polysaccharide fluffy aggregate (PSFA) technology with a facile and low-cost process. CMS-Na-P exhibited rapid water absorption capabilities alongside favorable cytocompatibility and hemocompatibility. Additionally, CMS-Na-P could absorb red blood cells (RBCs), adhere to and activate platelets, and shorten clotting time in vitro. More importantly, its good in vivo hemostatic ability was further demonstrated against hemorrhage in rat liver and tail, pig superficial skin, superficial body vein, superficial abdominal vein, and femoral artery. Meanwhile, in a rat full-thickness skin defect model, CMS-Na-P could enhance wound healing through accelerated epidermal regeneration and collagen deposition. These properties make CMS-Na-P a promising candidate for treating bleeding and full-thickness wounds.