Electrospun Fiber Mats with Metronidazole: Design, Evaluation, and Release Kinetics.

Abstract

Novel drug delivery systems (DDSs) strive to eliminate or at least reduce the side effects and limitations associated with conventional medical products. Among the many potential candidates for DDSs, there are one-dimensional micro- and nanostructured materials such as electrospun fibers. In this study, two different polymers, i.e., amphiphilic block copolymer (poly(2-vinylpyridine-co-styrene)) and hydrophobic polymer (polycaprolactone), were utilized as base materials for fibers. Through the electrospinning and coaxial electrospinning techniques, fibers with diverse architectures were obtained, homogeneous or core/shell structures. An antibacterial drug (metronidazole) in varying concentrations was incorporated into the electrospun fibers. The potential application of the obtained electrospun fiber mats is as a dressing for wounds or the treatment of periodontitis. The average diameter of fibers fell within the range of 700-1300 nm, with a drug content of 7-27 wt %. The amorphization or decrease in crystallinity of metronidazole present in the fibers was achieved during the electrospinning process. In vitro drug release tests showed that burst effects can be successfully suppressed, and more sustained release can be accomplished for some formulations. Therefore, electrospun polymer fiber mats are promising candidates for the local delivery of active substances.