Association of Chronic Kidney Disease With Increased Glucose Uptake–Associated Metabolic Activity of Visceral Adipose and Subcutaneous Adipose Tissue in Patients With Gout

IF 3.3 2区医学 Q1 RHEUMATOLOGY Arthritis Care & Research Pub Date : 2025-04-02 DOI:10.1002/acr.25540

Shunya Kaneshita, Sho Fukui, Soheil Niku, Kwanghoon Lee, Ernest Belezzuoli, Robert Terkeltaub, Monica Guma

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Abstract

Objective

We evaluate the ¹⁸F-fluorodeoxyglucose positron emission tomography (PET) standardized uptake value (SUV) by PET/computed tomography (CT) scans in visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) in patients with and without gout. Additionally, we investigate whether glucose uptake in these tissues predicts the progression of chronic kidney disease (CKD).

Methods

We used International Classification of Diseases, Tenth Revision codes from the University of California San Diego patient database to identify patients with gout and controls, forming a cohort of individuals who underwent PET/CT scans. The mean VAT and SAT maximum SUV (SUVmax) were measured using PET/CT scans and adjusted for potential confounders using inverse probability of weighting analysis. We also employed multivariable linear regression to analyze changes in estimated glomerular filtration rate (eGFR) after PET/CT scans.

Results

The study included 221 patients, with 120 diagnosed with gout. After the inverse probability of weighting adjustment, the mean VAT and SAT SUVmax were higher in patients with gout (mean VAT SUVmax: β = 0.09, 95% confidence interval [CI] 0.04–0.15; mean SAT SUVmax: β = 0.06, 95% CI 0.01–0.12). Additionally, in patients with gout with CKD stage ≥3, higher mean VAT and SAT SUVmax were associated with decreased eGFR in the 5 years following PET/CT scans (mean VAT SUVmax: β = −1.76, 95% CI −3.50 to −0.01; mean SAT SUVmax: β = −2.97, 95% CI −5.61 to −0.32).

Conclusion

Elevated glucose uptake–associated metabolic activity in both VAT and SAT was observed in patients with gout, which may contribute to CKD progression among patients with both gout and CKD.

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慢性肾脏疾病与痛风患者内脏脂肪和皮下脂肪组织葡萄糖摄取相关代谢活动增加有关

目的：通过PET/CT评估痛风患者和非痛风患者内脏脂肪组织（VAT）和皮下脂肪组织（SAT）中18f -氟脱氧葡萄糖（18F-FDG） PET标准化摄取值（SUV）。此外，我们研究了这些组织中的葡萄糖摄取是否能预测慢性肾脏疾病（CKD）的进展。方法：我们使用来自加州大学圣地亚哥分校患者数据库的ICD-10代码来识别痛风患者和对照组，形成一个接受PET/CT扫描的个体队列。使用PET/CT测量平均VAT和SAT SUVmax，并使用逆概率加权分析调整潜在混杂因素。我们还采用多变量线性回归分析PET/CT后肾小球滤过率（eGFR）的变化。结果：研究纳入221例患者，其中120例诊断为痛风。加权逆概率调整后，痛风患者的平均VAT和SAT SUVmax较高(平均VAT SUVmax: β=0.09, 95% CI=0.04 ~ 0.15；平均SAT SUVmax: β=0.06, 95% CI=0.01 ~ 0.12)。此外，在CKD 3期及以上的痛风患者中，较高的平均VAT和SAT SUVmax与PET/CT后5年内eGFR下降相关(平均VAT SUVmax: β=-1.76, 95% CI=-3.50至-0.01；平均SAT SUVmax: β=-2.97, 95% CI=-5.61至-0.32)结论：在痛风患者中观察到VAT和SAT中葡萄糖摄取相关代谢活性升高，这可能有助于痛风和CKD患者的CKD进展。

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来源期刊

Arthritis Care & Research RHEUMATOLOGY-

CiteScore

9.40

自引率

6.40%

发文量

368

审稿时长

3-6 weeks

期刊介绍： Arthritis Care & Research, an official journal of the American College of Rheumatology and the Association of Rheumatology Health Professionals (a division of the College), is a peer-reviewed publication that publishes original research, review articles, and editorials that promote excellence in the clinical practice of rheumatology. Relevant to the care of individuals with rheumatic diseases, major topics are evidence-based practice studies, clinical problems, practice guidelines, educational, social, and public health issues, health economics, health care policy, and future trends in rheumatology practice.