ECM-binding properties of extracellular vesicles: advanced delivery strategies for therapeutic applications in bone and joint diseases.

IF 8.2 2区生物学 Q1 CELL BIOLOGY Cell Communication and Signaling Pub Date : 2025-04-02 DOI:10.1186/s12964-025-02156-5

Peng Wang, Johanna F A Husch, Onno J Arntz, Peter M van der Kraan, Fons A J van de Loo, Jeroen J J P van den Beucken

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Abstract

Extracellular vesicles (EVs) and the extracellular matrix (ECM) are essential in maintaining bone and joint health by facilitating intercellular communication, regulating tissue processes and providing structural support. EVs with a large surface area carry diverse biomolecules to steer the function of cells in their surroundings. To understand how EVs localize to specific sites, we here review the available knowledge on EV surface biomolecules and their interactions with ECM components that are crucial for regulating bone remodeling, cartilage maintenance, and immune responses, playing roles in both tissue homeostasis and pathological conditions, such as arthritis and osteoporosis. More importantly, using analyses of animal experimental data, we illustrate the effect of ECM-based biomaterials (e.g. hydrogels, decellularized matrices, and ECM-mimetic scaffolds) as carriers for EVs toward effective EV delivery in regenerative and immunomodulatory therapies in bone and joint tissue. These biomaterials enable sustained release and targeted delivery of EVs, promoting bone and cartilage regeneration. The insights of this review can be utilized to advance the development of cutting-edge therapies for skeletal tissue regeneration and disease management.

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细胞外囊泡的ecm结合特性：用于骨和关节疾病治疗应用的先进递送策略

细胞外囊泡（EVs）和细胞外基质（ECM）通过促进细胞间交流、调节组织过程和提供结构支持，对维持骨骼和关节健康至关重要。EVs具有较大的表面积，可携带多种生物分子，引导周围环境中细胞的功能。为了了解 EVs 如何定位到特定部位，我们在此回顾了有关 EV 表面生物大分子及其与 ECM 成分相互作用的现有知识，这些成分对调节骨重塑、软骨维护和免疫反应至关重要，在组织稳态和病理状况（如关节炎和骨质疏松症）中都发挥着作用。更重要的是，通过对动物实验数据的分析，我们说明了以 ECM 为基础的生物材料（如水凝胶、脱细胞基质和 ECM 模拟支架）作为 EVs 载体在骨和关节组织再生和免疫调节疗法中有效递送 EVs 的效果。这些生物材料可实现 EVs 的持续释放和定向递送，促进骨和软骨的再生。本综述的见解可用于推动骨骼组织再生和疾病管理尖端疗法的开发。

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来源期刊

Cell Communication and Signaling CELL BIOLOGY-

CiteScore

11.00

自引率

0.00%

发文量

180

期刊介绍： Cell Communication and Signaling (CCS) is a peer-reviewed, open-access scientific journal that focuses on cellular signaling pathways in both normal and pathological conditions. It publishes original research, reviews, and commentaries, welcoming studies that utilize molecular, morphological, biochemical, structural, and cell biology approaches. CCS also encourages interdisciplinary work and innovative models, including in silico, in vitro, and in vivo approaches, to facilitate investigations of cell signaling pathways, networks, and behavior. Starting from January 2019, CCS is proud to announce its affiliation with the International Cell Death Society. The journal now encourages submissions covering all aspects of cell death, including apoptotic and non-apoptotic mechanisms, cell death in model systems, autophagy, clearance of dying cells, and the immunological and pathological consequences of dying cells in the tissue microenvironment.