{"title":"Reductive Desulfonylation of Sulfonamides under Polysulfide Anions Photocatalysis","authors":"Zixuan Feng, Eugene Yew Kun Tan, Shunsuke Chiba","doi":"10.1021/acs.orglett.5c01013","DOIUrl":null,"url":null,"abstract":"We demonstrate that polysulfide anions are capable of catalyzing desulfonylation of sulfonamides having a series of aryl and alkyl substituents in the presence of potassium formate under irradiation with visible light. The developed protocol is operationally concise and cost-effective, representing a practical and sustainable synthetic tool for desulfonylation and expanding the chemical space in secondary amine synthesis.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"6 1","pages":""},"PeriodicalIF":5.0000,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Letters","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1021/acs.orglett.5c01013","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
We demonstrate that polysulfide anions are capable of catalyzing desulfonylation of sulfonamides having a series of aryl and alkyl substituents in the presence of potassium formate under irradiation with visible light. The developed protocol is operationally concise and cost-effective, representing a practical and sustainable synthetic tool for desulfonylation and expanding the chemical space in secondary amine synthesis.
期刊介绍：
Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.
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