Lei Wang, Ming-Jun Li, Qing-Hai Li, Peng Xu, Si-Qi Chen, Hui Xu, Ze Zhang
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引用次数: 0
Abstract
Under ball-milling and heating conditions, the cascade cyclization of arylidene isoxazolones with β‑carbonyl esters proceeded smoothly in the presence of catalytic amount of FeBr3, affording polysubstituted pyridines in moderate to excellent (68ￚ93%) yields. A plausible reaction mechanism involving Michael addition, isoxazolone ring-opening, decarboxylation, and dehydration-driven aromatization was proposed. This mechanochemical protocol offers advantages such as high atom economy, solvent-free conditions and scalability making it a sustainable alternative for pyridine synthesis.
期刊介绍：
Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.
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