Immune repertoire profiling uncovers pervasive T cell clonal expansions in benign prostatic hyperplasia.

IF 13.6 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Journal of Clinical Investigation Pub Date : 2025-04-03 eCollection Date: 2025-06-02 DOI:10.1172/JCI186939
Anna S Pollack, Christian A Kunder, Chandler C Ho, Josephine Chou, Andrew J Pollack, Rachel Lp Geisick, Bing M Zhang, Robert B West, James D Brooks, Jonathan R Pollack
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Abstract

We discovered T-cell clonal expansions in benign prostatic hyperplasia, indicative of a specific adaptive immune response and with implications for disease pathogenesis and new treatments.

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免疫组谱分析发现良性前列腺增生症中普遍存在的 T 细胞克隆扩增。
我们在良性前列腺增生中发现了t细胞克隆扩增,这表明了一种特异性的适应性免疫反应,并对疾病的发病机制和新的治疗方法具有指导意义。
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来源期刊
Journal of Clinical Investigation
Journal of Clinical Investigation 医学-医学:研究与实验
CiteScore
24.50
自引率
1.30%
发文量
1034
审稿时长
2 months
期刊介绍: The Journal of Clinical Investigation, established in 1924 by the ASCI, is a prestigious publication that focuses on breakthroughs in basic and clinical biomedical science, with the goal of advancing the field of medicine. With an impressive Impact Factor of 15.9 in 2022, it is recognized as one of the leading journals in the "Medicine, Research & Experimental" category of the Web of Science. The journal attracts a diverse readership from various medical disciplines and sectors. It publishes a wide range of research articles encompassing all biomedical specialties, including Autoimmunity, Gastroenterology, Immunology, Metabolism, Nephrology, Neuroscience, Oncology, Pulmonology, Vascular Biology, and many others. The Editorial Board consists of esteemed academic editors who possess extensive expertise in their respective fields. They are actively involved in research, ensuring the journal's high standards of publication and scientific rigor.
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