Behavioral effects of three synthetic tryptamine derivatives in rodents.

IF 5.5 3区医学 Q1 CLINICAL NEUROLOGY Journal of Psychopharmacology Pub Date : 2025-09-01 Epub Date: 2025-04-04 DOI:10.1177/02698811251330737

Rebecca D Hill, Ritu A Shetty, Nathalie Sumien, Jeanne Priddy, Michael J Forster, Michael B Gatch

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Abstract

Aims: New synthetic tryptamine derivatives have emerged in the underground market. They act on serotonin receptors mimicking the effects of hallucinogenic drugs such as DOM. The DEA has identified three tryptamine derivatives of concern, 5-MeO-DBT, 5-Cl-DMT, and 4-OH-MiPT.

Methods: Swiss Webster mice were tested for locomotor activity. Discriminative stimulus effects were tested in male Sprague-Dawley rats trained to discriminate DOM (0.5 mg/kg, 30-min pretreatment) from vehicle (0.9% saline).

Results: In the locomotor activity tests, DOM (ED₅₀ = 4.8 mg/kg) produced a 40-100-min depressant phase. 5-MeO-DBT (ID₅₀ = 16.5 mg/kg; ED₅₀ = 0.074 mg/kg) had a 50-min depressant phase and a 100-min stimulant phase. 5-Cl-DMT (ID₅₀ = 12.3 mg/kg; ED₅₀ = 6.1 mg/kg) produced a 20-40-min depressant phase and a 30-min stimulant phase. 4-OH-MiPT (ID₅₀ = 5.8 mg/kg; ED₅₀ = 0.6 mg/kg) had a 30-130-min depressant phase and a 50-minute stimulant phase. In the drug discrimination assay, 4-OH-MIPT (ED₅₀ = 0.77 mg/kg) was fully substituted, whereas 5-Cl-DMT partially substituted for the discriminative stimulus effects produced by DOM (ED₅₀ = 0.23 mg/kg). 5-MeO-DBT failed to substitute for the discriminative stimulus of DOM. 5-CL-DMT and 5-MeO-DBT decreased response rate.

Conclusion: The locomotor depressant effects of the three synthetic tryptamine derivatives were similar to DOM, but not as potent. In the drug discrimination assay, only 4-OH-MIPT was substituted fully for DOM. These results support the possibility that 4-OH-MIPT has abuse liability similar to DOM, whereas 5-MeO-DBT and 5-Cl-DMT may not.

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三种合成色胺衍生物对啮齿动物行为的影响。

目的：新的合成色胺衍生物已经出现在地下市场。它们作用于5 -羟色胺受体，模仿致幻药物（如DOM）的效果。DEA已经确定了三种关注的色胺衍生物，5-MeO-DBT， 5-Cl-DMT和4-OH-MiPT。方法：对小鼠进行运动活性测定。对雄性Sprague-Dawley大鼠进行区分DOM （0.5 mg/kg，预处理30 min）和对照物（0.9%生理盐水）的实验。结果：在运动活动试验中，DOM （ED50 = 4.8 mg/kg）产生40-100 min的抑制期。5-MeO-DBT (ID50 = 16.5 mg/kg；ED50 = 0.074 mg/kg)有50 min的抑制期和100 min的兴奋期。5-Cl-DMT (ID50 = 12.3 mg/kg；ED50 = 6.1 mg/kg)产生20-40分钟的抑制期和30分钟的兴奋期。4-OH-MiPT (ID50 = 5.8 mg/kg；ED50 = 0.6 mg/kg)的抑制期为30 ~ 130 min，兴奋期为50 min。在药物鉴别实验中，4-OH-MIPT （ED50 = 0.77 mg/kg）被完全取代，5-Cl-DMT部分取代DOM产生的鉴别刺激效应（ED50 = 0.23 mg/kg）。5-MeO-DBT不能替代DOM的判别刺激。5-CL-DMT和5-MeO-DBT降低了应答率。结论：三种合成色胺衍生物的运动抑制作用与DOM相似，但效果不如DOM。在药物鉴别实验中，只有4-OH-MIPT被DOM完全取代。这些结果支持4-OH-MIPT具有类似DOM的滥用倾向的可能性，而5-MeO-DBT和5-Cl-DMT可能没有。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Psychopharmacology 医学-精神病学

CiteScore

8.60

自引率

4.90%

发文量

126

审稿时长

3-8 weeks

期刊介绍： The Journal of Psychopharmacology is a fully peer-reviewed, international journal that publishes original research and review articles on preclinical and clinical aspects of psychopharmacology. The journal provides an essential forum for researchers and practicing clinicians on the effects of drugs on animal and human behavior, and the mechanisms underlying these effects. The Journal of Psychopharmacology is truly international in scope and readership.