Non-invasive brain stimulation to modulate neural activity in Parkinson’s disease

IF 8.2 1区 医学 Q1 NEUROSCIENCES NPJ Parkinson's Disease Pub Date : 2025-04-05 DOI:10.1038/s41531-025-00908-1
Manuel Bange, Rick C. G. Helmich, Aparna A. Wagle Shukla, Günther Deuschl, Muthuraman Muthuraman
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Abstract

Despite its potential to modulate brain and network activity, non-invasive brain stimulation is not yet clinically applied for treating Parkinson’s disease. We here review recent findings that illustrate how various non-invasive stimulation techniques can modify pathological and compensatory activities. Due to unavoidable heterogeneities and low effect sizes of the reviewed studies, a deeper understanding of the mechanisms of action will be critical for refining clinical effectiveness and generating consistent results.

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非侵入性脑刺激调节帕金森病的神经活动
尽管它有调节大脑和网络活动的潜力,但非侵入性脑刺激尚未临床应用于治疗帕金森病。我们在这里回顾了最近的研究结果,说明了各种非侵入性刺激技术如何改变病理和代偿活动。由于所回顾的研究不可避免地存在异质性和低效应量,因此更深入地了解作用机制对于提高临床疗效和产生一致的结果至关重要。
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来源期刊
NPJ Parkinson's Disease
NPJ Parkinson's Disease Medicine-Neurology (clinical)
CiteScore
9.80
自引率
5.70%
发文量
156
审稿时长
11 weeks
期刊介绍: npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.
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