A more irregular shape of white matter hyperintensities is associated with cognitive decline over five years in community-dwelling older adults

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY Neurobiology of Aging Pub Date : 2025-04-01 DOI:10.1016/j.neurobiolaging.2025.03.011

Jasmin Annica Kuhn-Keller , Sigurdur Sigurdsson , Lenore J. Launer , Mark A. van Buchem , Matthias J.P. van Osch , Vilmundur Gudnason , Jeroen de Bresser

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Abstract

WMH shape is associated with long-term risk for dementia after 10 years in community-dwelling older adults. The current study aimed to investigate the association of WMH shape and decline in three cognitive domains over five years’ time in community-dwelling older adults. The association of baseline WMH shape (solidity, convexity, concavity index, fractal dimension, and eccentricity) and cognitive decline over 5.2 ± 0.3 years (domains: memory, executive function, and processing speed) was investigated using linear regression models in the Age, Gene/Environment Susceptibility-Reykjavik (AGES) study (n = 2493). A more irregular shape of periventricular/confluent WMH was related to cognitive decline in the memory domain, the executive function domain, and the processing speed domain over five years (p < 0.05). No associations were found between deep WMH shape and decline in the cognitive domains. These findings show that WMH shape patterns may be indicative of relatively short-term cognitive decline in community-dwelling older adults. This supports the evidence of WMH shape being a valuable marker that may be used to assess and predict cognitive outcome related to cerebrovascular disease progression.

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在社区居住的老年人中，更不规则形状的白质高强度与五年以上的认知能力下降有关

在社区居住的老年人中，WMH形状与10年后患痴呆症的长期风险相关。目前的研究旨在调查社区居住的老年人WMH形状与五年内三个认知领域下降的关系。在年龄、基因/环境敏感性-雷克雅维克（AGES）研究（ = 2493）中，使用线性回归模型研究了基线WMH形状（坚实度、凸度、凹度指数、分形维数和偏心率）与5.2 ± 0.3年认知能力下降（领域：记忆、执行功能和处理速度）的关系。脑室周围/脑融合区WMH形状不规则与5年内记忆域、执行功能域和处理速度域的认知能力下降有关（p <； 0.05）。没有发现深层脑mh形状与认知领域衰退之间的联系。这些发现表明，WMH形状模式可能表明社区居住的老年人的相对短期认知能力下降。这支持了WMH形状是一种有价值的标记物的证据，可用于评估和预测与脑血管疾病进展相关的认知结果。

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来源期刊

Neurobiology of Aging 医学-老年医学

CiteScore

8.40

自引率

2.40%

发文量

225

审稿时长

67 days

期刊介绍： Neurobiology of Aging publishes the results of studies in behavior, biochemistry, cell biology, endocrinology, molecular biology, morphology, neurology, neuropathology, pharmacology, physiology and protein chemistry in which the primary emphasis involves mechanisms of nervous system changes with age or diseases associated with age. Reviews and primary research articles are included, occasionally accompanied by open peer commentary. Letters to the Editor and brief communications are also acceptable. Brief reports of highly time-sensitive material are usually treated as rapid communications in which case editorial review is completed within six weeks and publication scheduled for the next available issue.