Cover Feature: Nitrocyclopropanes as Valuable Building Blocks in Organic Synthesis and Biology: Exploring the Origin of the Nitro Group (Chem. Eur. J. 20/2025)
Andriani G. Chaidali, Michael A. Terzidis, Prof. Ioannis N. Lykakis
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引用次数: 0
Abstract
Nitrocyclopropanes, a special class of donor–acceptor cyclopropanes, are considered to be stepping stones in organic synthesis. Due to the versatile nature of the nitro group, they can be converted into other functional heterocyclic or scaffolds of higher structural complexity to provide access to biologically active molecules. In their Review (DOI: 10.1002/chem.202404791), A. G. Chaidali, M. A. Terzidis and I. N. Lykakis have gathered and categorised the various synthetic methodologies based on the origin of the nitro group. The results of an application-focused analysis highlight the importance of nitrocyclopropanes as key intermediates.
硝基环丙烷是一类特殊的供体-受体环丙烷，被认为是有机合成的垫脚石。由于硝基的多功能性，它们可以转化为其他功能性杂环或结构更复杂的支架，从而获得具有生物活性的分子。在他们的综述（DOI: 10.1002/chem.202404791）中，A. G. Chaidali、M. A. Terzidis 和 I. N. G. Chaidali 分别介绍了硝基化合物的结构。Terzidis 和 I. N.Lykakis 根据硝基的来源收集并分类了各种合成方法。以应用为重点的分析结果突出了硝基环丙烷作为关键中间体的重要性。
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