Biomimetic Copper-Based Nanoplatform for Enhanced Tumor Targeting and Effective Melanoma Therapy.

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2025-04-21 Epub Date: 2025-04-05 DOI:10.1021/acsabm.5c00074

Hagar Shendy Bahlol, Kai Zhang, Jiamin Deng, Weiyun Zhang, Zhaoyu Ma, Jin Zhang, Heyou Han

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Abstract

Designing advanced biomimetic nanoplatforms that combine photothermal therapy (PTT) and immune activation represents a modern approach to addressing the challenges of cancer therapy. This study presents a nanobiomimetic hollow copper-sulfide (HCuS) platform for precise homotypic tumor targeting and melanoma treatment. The HCuS@OVA@CM (COC) nanoplatform-encapsulated ovalbumin (OVA) antigen protein within HCuS nanoparticles and was coated with melanoma cell membranes (B16F10). Importantly, this design facilitates specific tumor accumulation and achieves 16.0% photothermal conversion efficiency under 1064 nm NIR-II irradiation, which is a key factor for therapeutic success. In vitro studies have demonstrated that this nanoplatform induces immunogenic cell death (ICD), enhances antigen presentation, and stimulates dendritic cell (DCs) maturation. In vivo experiments confirmed that COC-mediated NIR-II photothermal treatment significantly suppressed tumor growth without notable body weight loss. This biomimetic nanoplatform approach offers a targeted, enhanced, and effective immune response for tumor photothermal immunotherapy, making it a promising candidate for advanced melanoma treatment and anticancer therapy.

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用于增强肿瘤靶向性和有效治疗黑色素瘤的仿生铜基纳米平台

设计先进的仿生纳米平台，将光热疗法（PTT）和免疫激活结合起来，是应对癌症治疗挑战的一种现代方法。本研究提出了一种用于精确同型肿瘤靶向和黑色素瘤治疗的纳米仿生空心硫化铜（HCuS）平台。HCuS@OVA@CM (COC) 纳米平台在 HCuS 纳米颗粒中封装了卵清蛋白（OVA）抗原蛋白，并包覆了黑色素瘤细胞膜（B16F10）。重要的是，这种设计有利于特异性肿瘤蓄积，并在 1064 纳米近红外-II 光照射下实现了 16.0% 的光热转换效率，这是治疗成功的关键因素。体外研究表明，这种纳米平台可诱导免疫原性细胞死亡（ICD），增强抗原递呈，刺激树突状细胞（DCs）成熟。体内实验证实，COC 介导的近红外-II 光热治疗可显著抑制肿瘤生长，且体重不会明显减轻。这种生物仿生纳米平台方法为肿瘤光热免疫疗法提供了靶向、增强和有效的免疫反应，使其成为晚期黑色素瘤治疗和抗癌疗法的理想候选药物。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.