{"title":"Fabrication of porous nano silica materials by template-assisted strategy for controlled drug delivery studies","authors":"Suman Chirra, Sripal Reddy Gujjula, Sathish Manda, Srinath Goskula, Venkatathri Narayanan","doi":"10.1007/s10934-024-01735-0","DOIUrl":null,"url":null,"abstract":"<div><p>The sol-gel method was employed to synthesize three-dimensional mesoporous Fe-KIT-6 and KIT-6. These materials were investigated for their potential in controlled drug delivery applications, with ibuprofen used as a model drug. Both Fe-KIT-6 and KIT-6 exhibit large pore volumes, narrow pore size distributions, and high surface areas, making them promising candidates for drug adsorption. The introduction of iron into the KIT-6 structure significantly enhanced its drug sorption capacity, with the materials showing an increased ability to adsorb ibuprofen as the iron content increased. Moreover, the release of ibuprofen was more efficient from iron-modified KIT-6, with materials containing iron exhibiting slower and more controlled drug release profiles. These results suggest that Fe-KIT-6 has potential for use in sustained-release drug delivery systems.</p></div>","PeriodicalId":660,"journal":{"name":"Journal of Porous Materials","volume":"32 2","pages":"761 - 772"},"PeriodicalIF":3.2000,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Porous Materials","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s10934-024-01735-0","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
The sol-gel method was employed to synthesize three-dimensional mesoporous Fe-KIT-6 and KIT-6. These materials were investigated for their potential in controlled drug delivery applications, with ibuprofen used as a model drug. Both Fe-KIT-6 and KIT-6 exhibit large pore volumes, narrow pore size distributions, and high surface areas, making them promising candidates for drug adsorption. The introduction of iron into the KIT-6 structure significantly enhanced its drug sorption capacity, with the materials showing an increased ability to adsorb ibuprofen as the iron content increased. Moreover, the release of ibuprofen was more efficient from iron-modified KIT-6, with materials containing iron exhibiting slower and more controlled drug release profiles. These results suggest that Fe-KIT-6 has potential for use in sustained-release drug delivery systems.
期刊介绍：
The Journal of Porous Materials is an interdisciplinary and international periodical devoted to all types of porous materials. Its aim is the rapid publication
of high quality, peer-reviewed papers focused on the synthesis, processing, characterization and property evaluation of all porous materials. The objective is to
establish a unique journal that will serve as a principal means of communication for the growing interdisciplinary field of porous materials.
Porous materials include microporous materials with 50 nm pores.
Examples of microporous materials are natural and synthetic molecular sieves, cationic and anionic clays, pillared clays, tobermorites, pillared Zr and Ti
phosphates, spherosilicates, carbons, porous polymers, xerogels, etc. Mesoporous materials include synthetic molecular sieves, xerogels, aerogels, glasses, glass
ceramics, porous polymers, etc.; while macroporous materials include ceramics, glass ceramics, porous polymers, aerogels, cement, etc. The porous materials
can be crystalline, semicrystalline or noncrystalline, or combinations thereof. They can also be either organic, inorganic, or their composites. The overall
objective of the journal is the establishment of one main forum covering the basic and applied aspects of all porous materials.
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