S. S. Starnovskaya, N. N. Kirichuk, V. E. Chausova, U. V. Khudyakova, E. A. Chingizova, A. R. Chingizov, A. N. Yurchenko, E. A. Yurchenko
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引用次数: 0
Abstract
The marine fungal strain KMM 4719 was isolated from the sea cucumber Apostichopus japonicus and identified as Penicillium polonicum based on three molecular genetic markers: ITS,BenA, and CaM. 3-O-methylviridicatin was isolated from the ethyl acetate extract of the strain culture. 3-O-methylviridicatin has demonstrated cardioprotective activity for the first time, as well as urease inhibitory activity (IC50 97.3 μM). In addition, 3-O-methylviridicatin at a concentration of 100 μM (25.1 μg/mL) inhibited the growth of the yeast-like fungus Candida albicans at 23.2%.
从海参Apostichopus japonicus中分离到一株海洋真菌kmm4719，经ITS、BenA和CaM分子遗传标记鉴定为polonicum。从菌株培养的乙酸乙酯萃取物中分离到3- o -甲基vi病菌素。3- o -甲基vi滑稽蛋白首次显示出心脏保护活性，并具有脲酶抑制活性（IC50为97.3 μM）。此外，浓度为100 μM （25.1 μg/mL）的3- o -甲基vipcatin对酵母样真菌白色念珠菌的生长抑制率为23.2%。
期刊介绍：
Applied Biochemistry and Microbiology is an international peer reviewed journal that publishes original articles on biochemistry and microbiology that have or may have practical applications. The studies include: enzymes and mechanisms of enzymatic reactions, biosynthesis of low and high molecular physiologically active compounds; the studies of their structure and properties; biogenesis and pathways of their regulation; metabolism of producers of biologically active compounds, biocatalysis in organic synthesis, applied genetics of microorganisms, applied enzymology; protein and metabolic engineering, biochemical bases of phytoimmunity, applied aspects of biochemical and immunochemical analysis; biodegradation of xenobiotics; biosensors; biomedical research (without clinical studies). Along with experimental works, the journal publishes descriptions of novel research techniques and reviews on selected topics.
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