Xuqing Huang, Yuyue Jiang, Xuqing Huang, Yuezhong Shen, Yan Wang, Xi Wang, Changqing Xu
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引用次数: 0
Abstract
Introduction: This study aimed to systematically review and summarize epidemiological evidence on the relationship between allergic diseases and migraine outcomes.
Methods: This meta-analysis, which was registered with PROSPERO (CRD420250656492), employed data from PubMed, Embase, the Cochrane Library, and references from the studies included in the review. The search encompassed literature from the inception of these databases through February 24, 2025. We included observational studies investigating the association between allergic diseases and migraine. The risk of bias was assessed using the Newcastle-Ottawa Quality Assessment Scale (NOS). Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using a random-effects model.
Results: A total of 10 studies encompassing 14,952,953 participants were included. The overall risk for migraine in patients with allergic diseases was 1.52 (95% CI: 1.40-1.65). Specifically, the meta-analysis revealed an OR for atopic dermatitis of 1.27 (1.17-1.38), 1.49 (95% CI 1.32-1.68) for asthma, 2.16 (95% CI 1.43-3.24) for allergic rhinitis, and 1.74 (95% CI 1.43-2.10) for allergic conjunctivitis.
Conclusion: The current meta-analysis suggests that allergic diseases are associated with an increased risk of developing migraines. However, further large-scale prospective cohort studies are required to validate the proposed association, considering the considerable heterogeneity observed in our analyses.
本研究旨在系统回顾和总结变态反应性疾病与偏头痛预后关系的流行病学证据。方法：本荟萃分析已在PROSPERO注册（CRD420250656492），数据来自PubMed、Embase、Cochrane图书馆，以及纳入综述的研究的参考文献。检索涵盖了从这些数据库建立之初到2025年2月24日的文献。我们纳入了调查过敏性疾病和偏头痛之间关系的观察性研究。偏倚风险采用纽卡斯尔-渥太华质量评估量表（NOS）进行评估。采用随机效应模型计算合并优势比（OR）和95%置信区间（CI）。结果：共纳入10项研究，涉及14952953名受试者。过敏性疾病患者偏头痛的总风险为1.52 （95% CI: 1.40-1.65）。具体来说，荟萃分析显示特应性皮炎的OR为1.27(1.17-1.38)，哮喘的OR为1.49 (95% CI 1.32-1.68)，过敏性鼻炎的OR为2.16 (95% CI 1.43-3.24)，过敏性结膜炎的OR为1.74 （95% CI 1.43-2.10）。结论：目前的荟萃分析表明，过敏性疾病与偏头痛发病风险增加有关。然而，考虑到我们的分析中观察到的相当大的异质性，需要进一步的大规模前瞻性队列研究来验证所提出的关联。
期刊介绍：
''International Archives of Allergy and Immunology'' provides a forum for basic and clinical research in modern molecular and cellular allergology and immunology. Appearing monthly, the journal publishes original work in the fields of allergy, immunopathology, immunogenetics, immunopharmacology, immunoendocrinology, tumor immunology, mucosal immunity, transplantation and immunology of infectious and connective tissue diseases.
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