{"title":"Periodontitis as a risk factor for colorectal cancer: systematic review and meta-analysis.","authors":"R-E Espejo-Carrera, T-M Honores-Solano, T-V Ulloa-Cueva, J-A Caballero-Alvarado, C-A Minchón-Medina, A-S Asmat-Abanto","doi":"10.4317/medoral.27118","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Primary studies on the association between periodontitis and colorectal cancer (CRC) may have insufficient statistical power to reach a reliable conclusion. In this regard, the present systematic review and meta-analysis were conducted to determine whether periodontitis is a risk factor for CRC.</p><p><strong>Material and methods: </strong>A systematic search was carried out in five databases, which included cohort and case-control studies published up to July 3, 2024, in which periodontitis was evaluated as a risk factor for CRC using relative risk (RR), hazard ratio (HR) or odds ratio (OR). The Newcastle-Ottawa Scale (NOS) was used to assess the risk of bias, and the GRADE system was used to determine the certainty of the evidence.</p><p><strong>Results: </strong>Of 1476 articles retrieved, 8 cohort studies were included for qualitative analysis and meta-analysis. The overall synthesis showed that periodontitis is not a risk factor for CRC (RR=1.34; 95% CI: 0.96-1.89; p<0.09; I2=95%). In addition, subgroup analyses were performed according to gender, periodontitis diagnostic methods, and risk of bias, which led to the finding of an increased risk of CRC of 32% only for men with periodontitis (RR=1.32; 95% CI: 1.16-1.50; p<0.00001; I2=0%).</p><p><strong>Conclusions: </strong>Periodontitis is not a risk factor for CRC, with very low certainty of evidence. However, the analysis of subgroups by gender showed that it is a risk factor for CRC in men, with moderate certainty of evidence.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e568-e577"},"PeriodicalIF":2.1000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225763/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicina Oral Patologia Oral Y Cirugia Bucal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4317/medoral.27118","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
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Abstract
Background: Primary studies on the association between periodontitis and colorectal cancer (CRC) may have insufficient statistical power to reach a reliable conclusion. In this regard, the present systematic review and meta-analysis were conducted to determine whether periodontitis is a risk factor for CRC.
Material and methods: A systematic search was carried out in five databases, which included cohort and case-control studies published up to July 3, 2024, in which periodontitis was evaluated as a risk factor for CRC using relative risk (RR), hazard ratio (HR) or odds ratio (OR). The Newcastle-Ottawa Scale (NOS) was used to assess the risk of bias, and the GRADE system was used to determine the certainty of the evidence.
Results: Of 1476 articles retrieved, 8 cohort studies were included for qualitative analysis and meta-analysis. The overall synthesis showed that periodontitis is not a risk factor for CRC (RR=1.34; 95% CI: 0.96-1.89; p<0.09; I2=95%). In addition, subgroup analyses were performed according to gender, periodontitis diagnostic methods, and risk of bias, which led to the finding of an increased risk of CRC of 32% only for men with periodontitis (RR=1.32; 95% CI: 1.16-1.50; p<0.00001; I2=0%).
Conclusions: Periodontitis is not a risk factor for CRC, with very low certainty of evidence. However, the analysis of subgroups by gender showed that it is a risk factor for CRC in men, with moderate certainty of evidence.
期刊介绍：
1. Oral Medicine and Pathology:
Clinicopathological as well as medical or surgical management aspects of
diseases affecting oral mucosa, salivary glands, maxillary bones, as well as
orofacial neurological disorders, and systemic conditions with an impact on
the oral cavity.
2. Oral Surgery:
Surgical management aspects of diseases affecting oral mucosa, salivary glands,
maxillary bones, teeth, implants, oral surgical procedures. Surgical management
of diseases affecting head and neck areas.
3. Medically compromised patients in Dentistry:
Articles discussing medical problems in Odontology will also be included, with
a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients.
4. Implantology
5. Periodontology
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