The Application of Deep Brain Stimulation on Multiple Sclerosis Tremors and the Emerging Targets: A Mini-Review.

IF 2.8 3区医学 Q1 Pharmacology, Toxicology and Pharmaceutics Therapeutics and Clinical Risk Management Pub Date : 2025-04-03 eCollection Date: 2025-01-01 DOI:10.2147/TCRM.S505015

Zengrui Zhang, Haiyan Tang, Yang Li, Ying Tan

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Abstract

Multiple sclerosis (MS) tremors, which are a common cause of disability, do not always respond to pharmacological treatment. Contrastingly, deep brain stimulation (DBS) in the thalamic or subthalamic areas (especially in the zona incerta, ZI) has prompted a response in suppressing MS tremors. In this study, we searched the relevant literature to further investigate the positive and negative effects of using DBS planted in different brain areas to suppress MS tremors. The unique effects of GABAergic agents from the ZI pertain to both the basal ganglia thalamocortical and cerebellar thalamocortical loops, in addition to the brain stem motor effector, where tremor oscillation may be transmitted. From this, the ZI is an effective target for ameliorating MS tremors through surgical treatment. Stimulation of the ZI, even bilaterally, could better control MS tremors, and with fewer side effects than targeting the thalamic area. Thus, the ZI is a promising target for regulating MS tremors. This review on MS tremor suppression will help to further understand the benefits of DBS on the ZI compared to DBS on the thalamic area in terms of managing MS tremors.

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深部脑刺激在多发性硬化震颤中的应用及其新靶点综述。

多发性硬化症（MS）震颤，这是残疾的常见原因，并不总是反应药物治疗。相比之下，在丘脑或丘脑下区域（特别是在动带，ZI）的深部脑刺激（DBS）在抑制MS震颤方面产生了反应。本研究通过查阅相关文献，进一步探讨在不同脑区植入DBS抑制MS震颤的正、负作用。来自ZI的gaba能药物的独特作用涉及基底节区丘脑皮层和小脑丘脑皮层回路，以及脑干运动效应器，其中震颤振荡可能被传递。由此可见，ZI是通过手术治疗改善MS震颤的有效靶点。刺激ZI，即使是双侧，也能更好地控制MS震颤，而且副作用比靶向丘脑区域少。因此，ZI是调控MS震颤的一个有希望的靶点。这篇关于MS震颤抑制的综述将有助于进一步了解DBS对ZI的益处，与DBS对丘脑区域的益处相比，在管理MS震颤方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutics and Clinical Risk Management HEALTH CARE SCIENCES & SERVICES-

CiteScore

5.30

自引率

3.60%

发文量

139

审稿时长

16 weeks

期刊介绍： Therapeutics and Clinical Risk Management is an international, peer-reviewed journal of clinical therapeutics and risk management, focusing on concise rapid reporting of clinical studies in all therapeutic areas, outcomes, safety, and programs for the effective, safe, and sustained use of medicines, therapeutic and surgical interventions in all clinical areas. The journal welcomes submissions covering original research, clinical and epidemiological studies, reviews, guidelines, expert opinion and commentary. The journal will consider case reports but only if they make a valuable and original contribution to the literature. As of 18th March 2019, Therapeutics and Clinical Risk Management will no longer consider meta-analyses for publication. The journal does not accept study protocols, animal-based or cell line-based studies.