Analysis of linear growth during puberty.

T Tanaka, S Suwa, S Yokoya, I Hibi
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Abstract

Linear growth was analysed in 438 boys and 483 girls aged from 6 years to 17 years. Annual records of each subject were fitted by using a cubic spline function. Parameters characterizing the growth process, such as peak height velocity (PHV), age at PHV, and age at onset of the pubertal growth spurt (PGS), were calculated directly from the estimated curves. The mean age at PHV was 11.2 years in girls and 13.0 years in boys. The mean PHV was 8.7 cm/year in girls and 10.3 cm/year in boys. Age at PHV showed a significant negative correlation with PHV and total pubertal gain, and a significant positive correlation with height at onset of the PGS, age at onset of the PGS and height at PHV. When subjects were divided into three groups (early, average and late pubertal maturation) according to the age at PHV, no significant difference in mean final height was seen between these groups, though a significant difference in height was observed at 6 years of age. When the results were adjusted for the difference in height at 6 years, the age at PHV showed a significant positive correlation with final height. It is concluded that age at PHV influences the final height.

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青春期线性生长的分析。
对438名6岁至17岁的男孩和483名女孩进行了线性生长分析。利用三次样条函数拟合各学科的年记录。表征生长过程的参数,如峰高速度(PHV)、PHV年龄和青春期生长高峰开始年龄(PGS),直接从估计曲线中计算。PHV的平均年龄女孩为11.2岁,男孩为13.0岁。女孩平均PHV为8.7 cm/年,男孩为10.3 cm/年。PHV年龄与PHV、青春期总增重呈显著负相关,与PGS发病身高、PGS发病年龄、PHV身高呈显著正相关。将被试按PHV年龄分为青春期前期、平均期和后期期三组,各组最终平均身高差异无统计学意义,但6岁时身高差异有统计学意义。当校正6岁时身高差异时,PHV年龄与最终身高呈显著正相关。得出PHV年龄对最终高度有影响的结论。
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11th International Symposium on Growth and Growth Disorders. Proceedings of a meeting, Stockholm, Sweden, 26-27 April 1991. 12th International Symposium on Growth and Growth Disorders. Geneva, 25-26 October 1991. The carbohydrate-deficient glycoprotein syndrome. A new inherited multisystemic disease with severe nervous system involvement. Growth hormone treatment in short children with chronic renal failure and after renal transplantation: combined data from European clinical trials. The European Study Group. Growth response in prepubertal children with idiopathic growth hormone deficiency during the first two years of treatment with human growth hormone. Analysis of the Kabi Pharmacia International Growth Study.
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