Fabrication and optimization of highly porous electrospun PLA fibers: a comparative study with curcumin-loaded systems

IF 2.8 4区化学 Q3 POLYMER SCIENCE Journal of Polymer Research Pub Date : 2025-04-10 DOI:10.1007/s10965-025-04348-6

Maria Mathew, Sagitha Paroly, Sujith Athiyanathil

{"title":"Fabrication and optimization of highly porous electrospun PLA fibers: a comparative study with curcumin-loaded systems","authors":"Maria Mathew, Sagitha Paroly, Sujith Athiyanathil","doi":"10.1007/s10965-025-04348-6","DOIUrl":null,"url":null,"abstract":"<div><p>Highly porous electrospun poly (lactic acid) (PLA) fibers were fabricated using a non-solvent induced phase separation (NIPS) mechanism, utilizing chloroform (CHL) as the good solvent and dimethyl formamide (DMF), dimethyl acetamide (DMAc), dimethyl sulfoxide (DMSO), and N, N- dimethyl pyrrolidone (NMP) as non-solvents. Optimal porosity was obtained with the DMF and DMAc systems, producing bead-free fibers with an average fiber diameter of 1–2 μm. Curcumin (Cur) was incorporated into both porous and non-porous PLA fibers. The porous and non-porous PLA/Cur composite membranes were characterized using FESEM, FTIR, XRD, TGA, DSC, tensile test (UTM), water contact angle measurement, water vapor transmission rate (WVTR) and cumulative curcumin release. The porous PLA/Cur membranes exhibited enhanced thermal stability, tensile strength, and water vapor transmission, along with a slower and, sustained release of curcumin, making them suitable for drug delivery, food packaging, sensing, and other environmental applications.</p><h3>Graphical abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":658,"journal":{"name":"Journal of Polymer Research","volume":"32 4","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Polymer Research","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10965-025-04348-6","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}

引用次数: 0

Abstract

Highly porous electrospun poly (lactic acid) (PLA) fibers were fabricated using a non-solvent induced phase separation (NIPS) mechanism, utilizing chloroform (CHL) as the good solvent and dimethyl formamide (DMF), dimethyl acetamide (DMAc), dimethyl sulfoxide (DMSO), and N, N- dimethyl pyrrolidone (NMP) as non-solvents. Optimal porosity was obtained with the DMF and DMAc systems, producing bead-free fibers with an average fiber diameter of 1–2 μm. Curcumin (Cur) was incorporated into both porous and non-porous PLA fibers. The porous and non-porous PLA/Cur composite membranes were characterized using FESEM, FTIR, XRD, TGA, DSC, tensile test (UTM), water contact angle measurement, water vapor transmission rate (WVTR) and cumulative curcumin release. The porous PLA/Cur membranes exhibited enhanced thermal stability, tensile strength, and water vapor transmission, along with a slower and, sustained release of curcumin, making them suitable for drug delivery, food packaging, sensing, and other environmental applications.

Graphical abstract

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

高孔静电纺PLA纤维的制备与优化：与姜黄素负载系统的比较研究

以氯仿（CHL）为良好溶剂，二甲甲酰胺（DMF）、二甲乙酰胺（DMAc）、二甲亚砜（DMSO）和N， N-二甲基吡咯烷酮（NMP）为非溶剂，采用非溶剂诱导相分离（NIPS）机理制备了高孔聚乳酸（PLA）静电纺丝纤维。DMF和DMAc体系的孔隙率最佳，制备的无珠纤维平均直径为1 ~ 2 μm。将姜黄素（Cur）掺入多孔和非多孔PLA纤维中。采用FESEM、FTIR、XRD、TGA、DSC、拉伸测试（UTM）、水接触角测试、水蒸气透过率（WVTR）和姜黄素累积释放量对多孔和无孔PLA/Cur复合膜进行了表征。多孔PLA/Cur膜表现出增强的热稳定性、抗拉强度和水蒸气透射性，以及姜黄素的缓慢和持续释放，使其适用于药物输送、食品包装、传感和其他环境应用。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Journal of Polymer Research 化学-高分子科学

CiteScore

4.70

自引率

7.10%

发文量

472

审稿时长

3.6 months

期刊介绍： Journal of Polymer Research provides a forum for the prompt publication of articles concerning the fundamental and applied research of polymers. Its great feature lies in the diversity of content which it encompasses, drawing together results from all aspects of polymer science and technology. As polymer research is rapidly growing around the globe, the aim of this journal is to establish itself as a significant information tool not only for the international polymer researchers in academia but also for those working in industry. The scope of the journal covers a wide range of the highly interdisciplinary field of polymer science and technology, including: polymer synthesis; polymer reactions; polymerization kinetics; polymer physics; morphology; structure-property relationships; polymer analysis and characterization; physical and mechanical properties; electrical and optical properties; polymer processing and rheology; application of polymers; supramolecular science of polymers; polymer composites.