Psychoeducational Program Increases Telomerase Activity in Bipolar Disorder: A Gender-Based Randomized Controlled Trial

IF 5 1区医学 Q1 NEUROSCIENCES CNS Neuroscience & Therapeutics Pub Date : 2025-04-09 DOI:10.1111/cns.70292

G. Massa, F. Bruno, L. Tarsitani, M. Caredda, M. Biondi, A. Bevilacqua, S. Canterini

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Abstract

Aims

This randomized controlled trial evaluated the efficacy of a psychoeducational program in enhancing telomerase activity (TA) among patients with bipolar disorder (BD), with a specific focus on gender differences.

Methods

A total of 62 participants were assigned to either the psychoeducation (PE) group or the control (CTR) group, with TA measured both before and after the intervention.

Results

Results demonstrated a significant increase in TA in the PE group compared to the controls at the conclusion of the study. Notably, gender-specific analyses revealed that female participants showed significant increases in both TA and delta TA (Δ_TA), with Δ_TA PE = 0.586 ± 0.273 and Δ_TA CTR = −0.251 ± 0.177. In contrast, male participants exhibited significant changes only in Δ_TA, with Δ_TA PE = 0.257 ± 0.138 and Δ_TA CTR = −0.144 ± 0.1194.

Conclusion

These findings suggest that psychoeducational interventions have differential gender-specific effects, underscoring the importance of personalized approaches in the treatment of BD.

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心理教育项目增加双相情感障碍患者端粒酶活性：一项基于性别的随机对照试验

目的：本随机对照试验评估心理教育项目在提高双相情感障碍（BD）患者端粒酶活性（TA）方面的疗效，并特别关注性别差异。方法将62名被试分为心理教育组（PE）和对照组（CTR），分别在干预前后测量TA。结果结果显示，在研究结束时，与对照组相比，PE组的TA显著增加。值得注意的是，性别分析显示，女性参与者的TA和delta TA均显著增加（ΔTA）， ΔTA PE = 0.586±0.273，ΔTA CTR = - 0.251±0.177。相比之下，男性参与者只有ΔTA表现出显著的变化，ΔTA PE = 0.257±0.138，ΔTA CTR = - 0.144±0.1194。结论这些发现提示心理教育干预具有不同性别的效果，强调个性化方法在双相障碍治疗中的重要性。

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来源期刊

CNS Neuroscience & Therapeutics 医学-神经科学

CiteScore

7.30

自引率

12.70%

发文量

240

审稿时长

2 months

期刊介绍： CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.