Noninvasive Temporal Interference Stimulation of the Subthalamic Nucleus in Parkinson's Disease Reduces Beta Activity

IF 7.6 1区医学 Q1 CLINICAL NEUROLOGY Movement Disorders Pub Date : 2025-04-09 DOI:10.1002/mds.30134

Martin Lamoš PhD, Martina Bočková MD, PhD, Florian Missey PhD, Claudia Lubrano PhD, Mariane de Araújo e Silva MSc, Jan Trajlínek MSc, Ondřej Studnička, Pavel Daniel MSc, Romain Carron MD, PhD, Viktor Jirsa PhD, Jan Chrastina MD, PhD, Radim Jančálek MD, PhD, Eric Daniel Glowacki PhD, Antonino Cassara PhD, Esra Neufeld PhD, Irena Rektorová MD, PhD, Adam Williamson PhD

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Abstract

Background

Temporal interference stimulation (TIS) is a novel noninvasive electrical stimulation technique to focally modulate deep brain regions; a minimum of two high-frequency signals (f₁ and f₂ > 1 kHz) interfere to create an envelope-modulated signal at a deep brain target with the frequency of modulation equal to the difference frequency: Δf = |f₂ – f₁|.

Objective

The goals of this study were to verify the capability of TIS to modulate the subthalamic nucleus (STN) with Δf and to compare the effect of TIS and conventional deep brain stimulation (DBS) on the STN beta oscillations in patients with Parkinson's disease (PD).

Methods

DBS leads remained externalized after implantation, allowing local field potentials (LFPs) recordings in eight patients with PD. TIS was performed initially by two pairs (f₁ = 9.00 kHz; f₂ = 9.13 kHz, 4 mA peak-peak per pair maximum) of scalp electrodes placed in temporoparietal regions to focus the envelope signal maximum (Δf = 130 Hz) at the motor part of the STN target.

Results

The comparison between the baseline LFPs and recordings after TIS and conventional DBS sessions showed substantial suppression of high beta power peak after both types of stimulation in all patients.

Conclusions

TIS has the potential to effectively modulate the STN and reduce the beta oscillatory activity in a completely noninvasive manner, as is traditionally possible only with intracranial DBS. Future studies should confirm the clinical effectiveness of TIS and determine whether TIS could be used to identify optimal DBS candidates and individualize DBS targets. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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帕金森氏病丘脑下核非侵入性颞干扰刺激减少β活性。

背景：颞干扰刺激（TIS）是一种新的无创电刺激技术，用于局部调节脑深部区域；至少有两个高频信号（f1和f2 > 1khz）相互干扰，在脑深部目标产生包络调制信号，其调制频率等于差频：Δf = |f2 - f1|。目的：本研究的目的是验证TIS通过Δf调节丘脑底核（STN）的能力，并比较TIS和常规深部脑刺激（DBS）对帕金森病（PD）患者丘脑底核β振荡的影响。方法：DBS导联植入后保持外置，对8例PD患者进行局部场电位（lfp）记录。TIS最初由两对(f1 = 9.00 kHz；f2 = 9.13 kHz，每对最大4 mA峰值)放置在颞顶区域的头皮电极，以最大限度地将包络信号（Δf = 130 Hz）聚焦在STN目标的运动部分。结果：基线lfp与TIS和常规DBS治疗后记录的比较显示，在所有患者中，两种刺激后的高β功率峰值均有明显抑制。结论：TIS具有以完全无创的方式有效调节STN和降低β振荡活动的潜力，传统上只有颅内DBS才有可能。未来的研究应证实TIS的临床有效性，并确定TIS是否可用于确定最佳DBS候选者和个体化DBS靶点。©2025作者。Wiley期刊有限责任公司代表国际帕金森和运动障碍学会出版的《运动障碍》。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Movement Disorders 医学-临床神经学

CiteScore

13.30

自引率

8.10%

发文量

371

审稿时长

12 months

期刊介绍： Movement Disorders publishes a variety of content types including Reviews, Viewpoints, Full Length Articles, Historical Reports, Brief Reports, and Letters. The journal considers original manuscripts on topics related to the diagnosis, therapeutics, pharmacology, biochemistry, physiology, etiology, genetics, and epidemiology of movement disorders. Appropriate topics include Parkinsonism, Chorea, Tremors, Dystonia, Myoclonus, Tics, Tardive Dyskinesia, Spasticity, and Ataxia.