Redox-neutral-photocatalyzed decarboxylative radical addition/acyl migration cascade process: modular access to functionalized α-(hetero)aryl-α-aminoketones†

IF 2.7 3区 化学 Q1 CHEMISTRY, ORGANIC Organic & Biomolecular Chemistry Pub Date : 2025-03-24 DOI:10.1039/d5ob00290g
Haibo Huang , Yu Zhao , Li Zhang , Yan Li , Yewen Fang
{"title":"Redox-neutral-photocatalyzed decarboxylative radical addition/acyl migration cascade process: modular access to functionalized α-(hetero)aryl-α-aminoketones†","authors":"Haibo Huang ,&nbsp;Yu Zhao ,&nbsp;Li Zhang ,&nbsp;Yan Li ,&nbsp;Yewen Fang","doi":"10.1039/d5ob00290g","DOIUrl":null,"url":null,"abstract":"<div><div>Herein, using reductive radical-polar crossover as a key process, a robust and practical protocol for the N → C acyl migration reaction has been successfully developed. A variety of enamides could react with carboxylic acids for modular access to α-(hetero)aryl-α-aminoketones enabled by redox-neutral photocatalysis. This decarboxylative radical addition/acyl migration cascade process features a broad substrate scope, good functional compatibility, and mild reaction conditions.</div></div>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":"23 17","pages":"Pages 4079-4083"},"PeriodicalIF":2.7000,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic & Biomolecular Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1477052025002435","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0

Abstract

Herein, using reductive radical-polar crossover as a key process, a robust and practical protocol for the N → C acyl migration reaction has been successfully developed. A variety of enamides could react with carboxylic acids for modular access to α-(hetero)aryl-α-aminoketones enabled by redox-neutral photocatalysis. This decarboxylative radical addition/acyl migration cascade process features a broad substrate scope, good functional compatibility, and mild reaction conditions.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
氧化还原-中性光催化脱羧自由基加成/酰基迁移级联过程:模块化获得功能化α-(杂)芳基-α-氨基酮。
本文以还原自由基-极性交叉为关键过程,成功地建立了一个稳健实用的N→C酰基迁移反应方案。在氧化还原-中性光催化作用下,多种酰胺类化合物可与羧酸反应生成α-(杂)芳基-α-氨基酮。这种脱羧自由基加成/酰基迁移级联过程具有底物范围广、功能相容性好、反应条件温和等特点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry 化学-有机化学
CiteScore
5.50
自引率
9.40%
发文量
1056
审稿时长
1.3 months
期刊介绍: Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.
期刊最新文献
Four-component assembly of polysubstituted pyrimidines via dual C(sp3)-H functionalization of primary aliphatic amines. Recent advances in the synthesis and applications of oxaborole derivatives. Determinants of undesired α2-6-sialoside formation by PmST1 M144D. C(3)-H alkenylation of quinoxalin-2(1H)-ones with Hantzsch esters and in silico studies. Synthesis of 4-amino-7-oxyindoles via dearomatization of 4-alkyl-2-alkynylanilines and dual fragment incorporation with O-benzoylhydroxylamines.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1